MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan

Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that M...

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Autores principales: Tian, Mingfu, Huang, Yuqing, Song, Yunting, Li, Wen, Zhao, Peiyi, Liu, Weiyong, Wu, Kailang, Wu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055/
https://www.ncbi.nlm.nih.gov/pubmed/33240758
http://dx.doi.org/10.1002/advs.202001950
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author Tian, Mingfu
Huang, Yuqing
Song, Yunting
Li, Wen
Zhao, Peiyi
Liu, Weiyong
Wu, Kailang
Wu, Jianguo
author_facet Tian, Mingfu
Huang, Yuqing
Song, Yunting
Li, Wen
Zhao, Peiyi
Liu, Weiyong
Wu, Kailang
Wu, Jianguo
author_sort Tian, Mingfu
collection PubMed
description Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that MYSM1 is a key suppressor of aging and aging‐related pathologies. MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. MYSM1 mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, MYSM1 deficiency facilitates the aging process and reduces lifespan, whereas MYSM1 over‐expression attenuates the aging process and increases lifespan in mice. The functional role of MYSM1 is demonstrated in suppressing the aging process and prolonging lifespan. MYSM1 is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging‐associated diseases.
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spelling pubmed-76750552020-11-24 MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan Tian, Mingfu Huang, Yuqing Song, Yunting Li, Wen Zhao, Peiyi Liu, Weiyong Wu, Kailang Wu, Jianguo Adv Sci (Weinh) Full Papers Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that MYSM1 is a key suppressor of aging and aging‐related pathologies. MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. MYSM1 mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, MYSM1 deficiency facilitates the aging process and reduces lifespan, whereas MYSM1 over‐expression attenuates the aging process and increases lifespan in mice. The functional role of MYSM1 is demonstrated in suppressing the aging process and prolonging lifespan. MYSM1 is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging‐associated diseases. John Wiley and Sons Inc. 2020-09-30 /pmc/articles/PMC7675055/ /pubmed/33240758 http://dx.doi.org/10.1002/advs.202001950 Text en © 2020 The Authors. Published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Tian, Mingfu
Huang, Yuqing
Song, Yunting
Li, Wen
Zhao, Peiyi
Liu, Weiyong
Wu, Kailang
Wu, Jianguo
MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan
title MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan
title_full MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan
title_fullStr MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan
title_full_unstemmed MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan
title_short MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan
title_sort mysm1 suppresses cellular senescence and the aging process to prolong lifespan
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055/
https://www.ncbi.nlm.nih.gov/pubmed/33240758
http://dx.doi.org/10.1002/advs.202001950
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