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Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children
INTRODUCTION: The usefulness of total specific resistance (sRtot) and interrupter resistance (Rint) as a bronchodilator reversibility test (BT) alternative to forced expiratory volume in 1 s (FEV(1)) in asthma diagnosis in children has not been established. AIM: To compare different applied definiti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675071/ https://www.ncbi.nlm.nih.gov/pubmed/33240006 http://dx.doi.org/10.5114/ada.2019.85631 |
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author | Bobrowska-Korzeniowska, Monika Brzozowska, Agnieszka Jerzyńska, Joanna Stelmach, Włodzimierz Stelmach, Iwona |
author_facet | Bobrowska-Korzeniowska, Monika Brzozowska, Agnieszka Jerzyńska, Joanna Stelmach, Włodzimierz Stelmach, Iwona |
author_sort | Bobrowska-Korzeniowska, Monika |
collection | PubMed |
description | INTRODUCTION: The usefulness of total specific resistance (sRtot) and interrupter resistance (Rint) as a bronchodilator reversibility test (BT) alternative to forced expiratory volume in 1 s (FEV(1)) in asthma diagnosis in children has not been established. AIM: To compare different applied definitions of airflow obstruction in children measuring response to the bronchodilator by spirometry, plethysmography and the interrupter technique in asthmatic children. MATERIAL AND METHODS: It was a prospective, real-life, non-interventional study. Children, aged 6–18 with newly diagnosed asthma, able to perform lung function tests were included into the study. Subjects underwent a history taking, physical examination, reversibility test in spirometry, plethysmography, and the interrupter technique. A standard cut-off of 12% from the initial value for reversibility in FEV(1) was employed. Improvement in the pre-bronchodilator sRtot and Rint ≥ 25% and ≥ 35% was assessed after administration of salbutamol (400 µg) as well as allergen sensitization were measured. RESULTS: We included 135 children diagnosed with asthma into the analysis. All investigated parameters changed statistically significantly due to the bronchodilator administration in the examined patients. The FEV(1) was not as useful in diagnostics of asthma as the sRtot and Rint, taking into consideration the fait accompli that all the study participants had aptly been diagnosed as having asthma (p < 0.001). The differences between the sRtot and Rint were not statistically significant (p = 0.215). CONCLUSIONS: Our results suggest that sRtot and Rint may be useful parameters in BT in clinical practice in the asthma diagnostic process in children. |
format | Online Article Text |
id | pubmed-7675071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-76750712020-11-24 Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children Bobrowska-Korzeniowska, Monika Brzozowska, Agnieszka Jerzyńska, Joanna Stelmach, Włodzimierz Stelmach, Iwona Postepy Dermatol Alergol Original Paper INTRODUCTION: The usefulness of total specific resistance (sRtot) and interrupter resistance (Rint) as a bronchodilator reversibility test (BT) alternative to forced expiratory volume in 1 s (FEV(1)) in asthma diagnosis in children has not been established. AIM: To compare different applied definitions of airflow obstruction in children measuring response to the bronchodilator by spirometry, plethysmography and the interrupter technique in asthmatic children. MATERIAL AND METHODS: It was a prospective, real-life, non-interventional study. Children, aged 6–18 with newly diagnosed asthma, able to perform lung function tests were included into the study. Subjects underwent a history taking, physical examination, reversibility test in spirometry, plethysmography, and the interrupter technique. A standard cut-off of 12% from the initial value for reversibility in FEV(1) was employed. Improvement in the pre-bronchodilator sRtot and Rint ≥ 25% and ≥ 35% was assessed after administration of salbutamol (400 µg) as well as allergen sensitization were measured. RESULTS: We included 135 children diagnosed with asthma into the analysis. All investigated parameters changed statistically significantly due to the bronchodilator administration in the examined patients. The FEV(1) was not as useful in diagnostics of asthma as the sRtot and Rint, taking into consideration the fait accompli that all the study participants had aptly been diagnosed as having asthma (p < 0.001). The differences between the sRtot and Rint were not statistically significant (p = 0.215). CONCLUSIONS: Our results suggest that sRtot and Rint may be useful parameters in BT in clinical practice in the asthma diagnostic process in children. Termedia Publishing House 2020-11-07 2020-10 /pmc/articles/PMC7675071/ /pubmed/33240006 http://dx.doi.org/10.5114/ada.2019.85631 Text en Copyright © 2020 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Original Paper Bobrowska-Korzeniowska, Monika Brzozowska, Agnieszka Jerzyńska, Joanna Stelmach, Włodzimierz Stelmach, Iwona Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children |
title | Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children |
title_full | Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children |
title_fullStr | Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children |
title_full_unstemmed | Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children |
title_short | Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children |
title_sort | usefulness of srtot and rint in bronchodilator testing in the diagnosis of asthma in children |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675071/ https://www.ncbi.nlm.nih.gov/pubmed/33240006 http://dx.doi.org/10.5114/ada.2019.85631 |
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