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CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy

Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, in which the higher frequency of cancer stem cells (CSCs) correlates with the poor clinical outcome. An aberrant activation of CDK5 is found to associate with TNBC progression closely. CDK5 mediates PPARγ phosphory...

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Detalles Bibliográficos
Autores principales: Bei, Yuncheng, Cheng, Nan, Chen, Ting, Shu, Yuxin, Yang, Ye, Yang, Nanfei, Zhou, Xinyu, Liu, Baorui, Wei, Jia, Liu, Qin, Zheng, Wei, Zhang, Wenlong, Su, Huifang, Zhu, Wei‐Guo, Ji, Jianguo, Shen, Pingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675186/
https://www.ncbi.nlm.nih.gov/pubmed/33240752
http://dx.doi.org/10.1002/advs.202001417