Cargando…
CDK5 Inhibition Abrogates TNBC Stem‐Cell Property and Enhances Anti‐PD‐1 Therapy
Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, in which the higher frequency of cancer stem cells (CSCs) correlates with the poor clinical outcome. An aberrant activation of CDK5 is found to associate with TNBC progression closely. CDK5 mediates PPARγ phosphory...
Autores principales: | Bei, Yuncheng, Cheng, Nan, Chen, Ting, Shu, Yuxin, Yang, Ye, Yang, Nanfei, Zhou, Xinyu, Liu, Baorui, Wei, Jia, Liu, Qin, Zheng, Wei, Zhang, Wenlong, Su, Huifang, Zhu, Wei‐Guo, Ji, Jianguo, Shen, Pingping |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675186/ https://www.ncbi.nlm.nih.gov/pubmed/33240752 http://dx.doi.org/10.1002/advs.202001417 |
Ejemplares similares
-
Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages
por: Shu, Yuxin, et al.
Publicado: (2022) -
Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma
por: Bei, Yuncheng, et al.
Publicado: (2023) -
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions
por: Yang, Nanfei, et al.
Publicado: (2022) -
A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy
por: Sun, Luchen, et al.
Publicado: (2023) -
Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
por: Niu, Zhiyuan, et al.
Publicado: (2017)