Cargando…

COVID‐19 and the pulmonary complications of sickle cell disease

Sickle cell disease (SCD) patients are commonly affected by pulmonary complications such as acute chest syndrome (ACS), pulmonary embolism (PE) and pneumonia that contribute to significant mortality risks. With a greater susceptibility to infection, they are deemed to be vulnerable patients during t...

Descripción completa

Detalles Bibliográficos
Autores principales: Sivalingam, Thivya, Inusa, Baba, Doyle, Pat, Oteng‐Ntim, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675298/
https://www.ncbi.nlm.nih.gov/pubmed/33230510
http://dx.doi.org/10.1002/jha2.105
_version_ 1783611655637172224
author Sivalingam, Thivya
Inusa, Baba
Doyle, Pat
Oteng‐Ntim, Eugene
author_facet Sivalingam, Thivya
Inusa, Baba
Doyle, Pat
Oteng‐Ntim, Eugene
author_sort Sivalingam, Thivya
collection PubMed
description Sickle cell disease (SCD) patients are commonly affected by pulmonary complications such as acute chest syndrome (ACS), pulmonary embolism (PE) and pneumonia that contribute to significant mortality risks. With a greater susceptibility to infection, they are deemed to be vulnerable patients during the current COVID‐19 pandemic. In emerging small case studies of SCD patients with COVID‐19 and further complicated by pneumonia, ACS, and/or PE, the clinical benefits of early exchange transfusion and Tocilizumab are evident. However, further clinical trials and larger cohort studies are essential to evaluate effective diagnostic and management options for this high‐risk group.
format Online
Article
Text
id pubmed-7675298
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-76752982020-11-19 COVID‐19 and the pulmonary complications of sickle cell disease Sivalingam, Thivya Inusa, Baba Doyle, Pat Oteng‐Ntim, Eugene EJHaem Short Reports Sickle cell disease (SCD) patients are commonly affected by pulmonary complications such as acute chest syndrome (ACS), pulmonary embolism (PE) and pneumonia that contribute to significant mortality risks. With a greater susceptibility to infection, they are deemed to be vulnerable patients during the current COVID‐19 pandemic. In emerging small case studies of SCD patients with COVID‐19 and further complicated by pneumonia, ACS, and/or PE, the clinical benefits of early exchange transfusion and Tocilizumab are evident. However, further clinical trials and larger cohort studies are essential to evaluate effective diagnostic and management options for this high‐risk group. John Wiley and Sons Inc. 2020-10-08 /pmc/articles/PMC7675298/ /pubmed/33230510 http://dx.doi.org/10.1002/jha2.105 Text en © 2020 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Sivalingam, Thivya
Inusa, Baba
Doyle, Pat
Oteng‐Ntim, Eugene
COVID‐19 and the pulmonary complications of sickle cell disease
title COVID‐19 and the pulmonary complications of sickle cell disease
title_full COVID‐19 and the pulmonary complications of sickle cell disease
title_fullStr COVID‐19 and the pulmonary complications of sickle cell disease
title_full_unstemmed COVID‐19 and the pulmonary complications of sickle cell disease
title_short COVID‐19 and the pulmonary complications of sickle cell disease
title_sort covid‐19 and the pulmonary complications of sickle cell disease
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675298/
https://www.ncbi.nlm.nih.gov/pubmed/33230510
http://dx.doi.org/10.1002/jha2.105
work_keys_str_mv AT sivalingamthivya covid19andthepulmonarycomplicationsofsicklecelldisease
AT inusababa covid19andthepulmonarycomplicationsofsicklecelldisease
AT doylepat covid19andthepulmonarycomplicationsofsicklecelldisease
AT otengntimeugene covid19andthepulmonarycomplicationsofsicklecelldisease