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Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
INTRODUCTION: The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low‐dose mPSL. CASE PRESENTATION...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675346/ https://www.ncbi.nlm.nih.gov/pubmed/33230502 http://dx.doi.org/10.1002/iju5.12226 |
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author | Tanaka, Ryo Kakuta, Yoichi Tsutahara, Koichi Nakagawa, Masahiro Ichimaru, Naotsugu Sakaguchi, Katsuhiko Kato, Taigo Imamura, Ryoichi Nonomura, Norio Takao, Tetsuya |
author_facet | Tanaka, Ryo Kakuta, Yoichi Tsutahara, Koichi Nakagawa, Masahiro Ichimaru, Naotsugu Sakaguchi, Katsuhiko Kato, Taigo Imamura, Ryoichi Nonomura, Norio Takao, Tetsuya |
author_sort | Tanaka, Ryo |
collection | PubMed |
description | INTRODUCTION: The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low‐dose mPSL. CASE PRESENTATION: A 36‐year‐old man, who underwent living kidney transplantation 1.5 year prior, developed fever. After 10 days, he developed dyspnea, and his blood oxygen levels decreased. Computed tomography showed pulmonary ground‐glass shadow on both lungs, and the coronavirus disease 2019 real‐time polymerase chain reaction test was positive. After reducing the immunosuppressive agents, the C‐reactive protein levels continued elevating, and the pulmonary shadow spread. Subsequently, low‐dose methylprednisolone (40 mg/day) was administered for 4 days and his C‐reactive protein and blood oxygen levels increased and improved, respectively. The coronavirus disease 2019 real‐time polymerase chain reaction test was negative and the pulmonary shadow disappeared. CONCLUSION: Low‐dose methylprednisolone may prevent the development of severe coronavirus disease 2019. |
format | Online Article Text |
id | pubmed-7675346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76753462020-11-19 Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone Tanaka, Ryo Kakuta, Yoichi Tsutahara, Koichi Nakagawa, Masahiro Ichimaru, Naotsugu Sakaguchi, Katsuhiko Kato, Taigo Imamura, Ryoichi Nonomura, Norio Takao, Tetsuya IJU Case Rep Case Reports INTRODUCTION: The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low‐dose mPSL. CASE PRESENTATION: A 36‐year‐old man, who underwent living kidney transplantation 1.5 year prior, developed fever. After 10 days, he developed dyspnea, and his blood oxygen levels decreased. Computed tomography showed pulmonary ground‐glass shadow on both lungs, and the coronavirus disease 2019 real‐time polymerase chain reaction test was positive. After reducing the immunosuppressive agents, the C‐reactive protein levels continued elevating, and the pulmonary shadow spread. Subsequently, low‐dose methylprednisolone (40 mg/day) was administered for 4 days and his C‐reactive protein and blood oxygen levels increased and improved, respectively. The coronavirus disease 2019 real‐time polymerase chain reaction test was negative and the pulmonary shadow disappeared. CONCLUSION: Low‐dose methylprednisolone may prevent the development of severe coronavirus disease 2019. John Wiley and Sons Inc. 2020-10-05 /pmc/articles/PMC7675346/ /pubmed/33230502 http://dx.doi.org/10.1002/iju5.12226 Text en © 2020 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Tanaka, Ryo Kakuta, Yoichi Tsutahara, Koichi Nakagawa, Masahiro Ichimaru, Naotsugu Sakaguchi, Katsuhiko Kato, Taigo Imamura, Ryoichi Nonomura, Norio Takao, Tetsuya Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone |
title | Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone |
title_full | Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone |
title_fullStr | Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone |
title_full_unstemmed | Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone |
title_short | Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone |
title_sort | successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675346/ https://www.ncbi.nlm.nih.gov/pubmed/33230502 http://dx.doi.org/10.1002/iju5.12226 |
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