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Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone

INTRODUCTION: The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low‐dose mPSL. CASE PRESENTATION...

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Autores principales: Tanaka, Ryo, Kakuta, Yoichi, Tsutahara, Koichi, Nakagawa, Masahiro, Ichimaru, Naotsugu, Sakaguchi, Katsuhiko, Kato, Taigo, Imamura, Ryoichi, Nonomura, Norio, Takao, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675346/
https://www.ncbi.nlm.nih.gov/pubmed/33230502
http://dx.doi.org/10.1002/iju5.12226
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author Tanaka, Ryo
Kakuta, Yoichi
Tsutahara, Koichi
Nakagawa, Masahiro
Ichimaru, Naotsugu
Sakaguchi, Katsuhiko
Kato, Taigo
Imamura, Ryoichi
Nonomura, Norio
Takao, Tetsuya
author_facet Tanaka, Ryo
Kakuta, Yoichi
Tsutahara, Koichi
Nakagawa, Masahiro
Ichimaru, Naotsugu
Sakaguchi, Katsuhiko
Kato, Taigo
Imamura, Ryoichi
Nonomura, Norio
Takao, Tetsuya
author_sort Tanaka, Ryo
collection PubMed
description INTRODUCTION: The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low‐dose mPSL. CASE PRESENTATION: A 36‐year‐old man, who underwent living kidney transplantation 1.5 year prior, developed fever. After 10 days, he developed dyspnea, and his blood oxygen levels decreased. Computed tomography showed pulmonary ground‐glass shadow on both lungs, and the coronavirus disease 2019 real‐time polymerase chain reaction test was positive. After reducing the immunosuppressive agents, the C‐reactive protein levels continued elevating, and the pulmonary shadow spread. Subsequently, low‐dose methylprednisolone (40 mg/day) was administered for 4 days and his C‐reactive protein and blood oxygen levels increased and improved, respectively. The coronavirus disease 2019 real‐time polymerase chain reaction test was negative and the pulmonary shadow disappeared. CONCLUSION: Low‐dose methylprednisolone may prevent the development of severe coronavirus disease 2019.
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spelling pubmed-76753462020-11-19 Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone Tanaka, Ryo Kakuta, Yoichi Tsutahara, Koichi Nakagawa, Masahiro Ichimaru, Naotsugu Sakaguchi, Katsuhiko Kato, Taigo Imamura, Ryoichi Nonomura, Norio Takao, Tetsuya IJU Case Rep Case Reports INTRODUCTION: The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient. We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low‐dose mPSL. CASE PRESENTATION: A 36‐year‐old man, who underwent living kidney transplantation 1.5 year prior, developed fever. After 10 days, he developed dyspnea, and his blood oxygen levels decreased. Computed tomography showed pulmonary ground‐glass shadow on both lungs, and the coronavirus disease 2019 real‐time polymerase chain reaction test was positive. After reducing the immunosuppressive agents, the C‐reactive protein levels continued elevating, and the pulmonary shadow spread. Subsequently, low‐dose methylprednisolone (40 mg/day) was administered for 4 days and his C‐reactive protein and blood oxygen levels increased and improved, respectively. The coronavirus disease 2019 real‐time polymerase chain reaction test was negative and the pulmonary shadow disappeared. CONCLUSION: Low‐dose methylprednisolone may prevent the development of severe coronavirus disease 2019. John Wiley and Sons Inc. 2020-10-05 /pmc/articles/PMC7675346/ /pubmed/33230502 http://dx.doi.org/10.1002/iju5.12226 Text en © 2020 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Tanaka, Ryo
Kakuta, Yoichi
Tsutahara, Koichi
Nakagawa, Masahiro
Ichimaru, Naotsugu
Sakaguchi, Katsuhiko
Kato, Taigo
Imamura, Ryoichi
Nonomura, Norio
Takao, Tetsuya
Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
title Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
title_full Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
title_fullStr Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
title_full_unstemmed Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
title_short Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
title_sort successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low‐dose methylprednisolone
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675346/
https://www.ncbi.nlm.nih.gov/pubmed/33230502
http://dx.doi.org/10.1002/iju5.12226
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