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Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments

[Image: see text] A new theoretical model is formulated for the quantitative analysis of quartz crystal microbalance (QCM) response for heterogeneous loads consisting of nano- and microparticles. The influence of particle coverage and structure is described using a universal correction function in a...

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Autores principales: Adamczyk, Zbigniew, Sadowska, Marta, Żeliszewska, Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675609/
https://www.ncbi.nlm.nih.gov/pubmed/32957771
http://dx.doi.org/10.1021/acs.analchem.0c03115
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author Adamczyk, Zbigniew
Sadowska, Marta
Żeliszewska, Paulina
author_facet Adamczyk, Zbigniew
Sadowska, Marta
Żeliszewska, Paulina
author_sort Adamczyk, Zbigniew
collection PubMed
description [Image: see text] A new theoretical model is formulated for the quantitative analysis of quartz crystal microbalance (QCM) response for heterogeneous loads consisting of nano- and microparticles. The influence of particle coverage and structure is described using a universal correction function in an ab initio manner. Explicit analytical expressions for the frequency and dissipation shifts are derived for the entire range of particle size under the rigid contact regime. The solvent coupling functions are also calculated to determine the dry coverage using the QCM measurements. These expressions furnish the upper limit of the QCM signal, which can be attained for a sensor providing perfect adhesion of particles. Correction functions accounting for the finite adhesion strength (soft contact regime) are also derived. The theoretical results are confronted with QCM and atomic force microscopy measurements of positively charged polymer particle deposition on silica sensors. The main features of the theoretical model are confirmed, especially the abrupt decrease in the QCM wet mass with the particle coverage and the overtone number. The latter effect is especially pronounced for microparticles under the soft contact regime, where the higher-number overtones produce a negligible QCM signal. These results represent a useful reference data for the interpretation of protein and bioparticles, for example, virus and bacteria attachment processes to various substrates.
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spelling pubmed-76756092020-11-20 Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments Adamczyk, Zbigniew Sadowska, Marta Żeliszewska, Paulina Anal Chem [Image: see text] A new theoretical model is formulated for the quantitative analysis of quartz crystal microbalance (QCM) response for heterogeneous loads consisting of nano- and microparticles. The influence of particle coverage and structure is described using a universal correction function in an ab initio manner. Explicit analytical expressions for the frequency and dissipation shifts are derived for the entire range of particle size under the rigid contact regime. The solvent coupling functions are also calculated to determine the dry coverage using the QCM measurements. These expressions furnish the upper limit of the QCM signal, which can be attained for a sensor providing perfect adhesion of particles. Correction functions accounting for the finite adhesion strength (soft contact regime) are also derived. The theoretical results are confronted with QCM and atomic force microscopy measurements of positively charged polymer particle deposition on silica sensors. The main features of the theoretical model are confirmed, especially the abrupt decrease in the QCM wet mass with the particle coverage and the overtone number. The latter effect is especially pronounced for microparticles under the soft contact regime, where the higher-number overtones produce a negligible QCM signal. These results represent a useful reference data for the interpretation of protein and bioparticles, for example, virus and bacteria attachment processes to various substrates. American Chemical Society 2020-09-22 2020-11-17 /pmc/articles/PMC7675609/ /pubmed/32957771 http://dx.doi.org/10.1021/acs.analchem.0c03115 Text en © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Adamczyk, Zbigniew
Sadowska, Marta
Żeliszewska, Paulina
Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments
title Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments
title_full Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments
title_fullStr Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments
title_full_unstemmed Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments
title_short Applicability of QCM-D for Quantitative Measurements of Nano- and Microparticle Deposition Kinetics: Theoretical Modeling and Experiments
title_sort applicability of qcm-d for quantitative measurements of nano- and microparticle deposition kinetics: theoretical modeling and experiments
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675609/
https://www.ncbi.nlm.nih.gov/pubmed/32957771
http://dx.doi.org/10.1021/acs.analchem.0c03115
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