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Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability

Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and...

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Autores principales: Kandimalla, Raghuram, Das, Momita, Barge, Sagar R., Sarma, Partha Pratim, Koiri, Dibya Jyoti, Devi, Arundhuti, Karki, Arjun Kumar, Kumar, Anil, Devi, Rajlakshmi, Pal, Bikas C., Talukdar, Narayan C., Samanta, Suman Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675983/
https://www.ncbi.nlm.nih.gov/pubmed/33208840
http://dx.doi.org/10.1038/s41598-020-77113-y
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author Kandimalla, Raghuram
Das, Momita
Barge, Sagar R.
Sarma, Partha Pratim
Koiri, Dibya Jyoti
Devi, Arundhuti
Karki, Arjun Kumar
Kumar, Anil
Devi, Rajlakshmi
Pal, Bikas C.
Talukdar, Narayan C.
Samanta, Suman Kumar
author_facet Kandimalla, Raghuram
Das, Momita
Barge, Sagar R.
Sarma, Partha Pratim
Koiri, Dibya Jyoti
Devi, Arundhuti
Karki, Arjun Kumar
Kumar, Anil
Devi, Rajlakshmi
Pal, Bikas C.
Talukdar, Narayan C.
Samanta, Suman Kumar
author_sort Kandimalla, Raghuram
collection PubMed
description Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital bioactive phytochemical, mahanine in the MK leaves from different geographical locations of varying soil properties and weather parameters was determined. Accordingly, MK leaves and soil samples around the plant base in quintuplicate from each site across five states of India at similar time point were collected. Mahanine content was determined and compared among samples from different regions. The quantitative analysis data comprised that MK-leaves of southern part of India contains highest amount of mahanine, which is 16.9 times higher than that of MK-leaves of north-eastern part of India (which measured as the lowest). The results suggested that pH, conductivity and bacterial populations of the soil samples were positively correlated with mahanine content in the MK-leaves. For examples, the average soil pH of the southern India sites was in basic range (8.8 ± 0.6); whereas that of the north-east India sites was in slightly acidic ranges (6.1 ± 0.5) and mean soil conductivity value for the north east India soils was 78.3 ± 16.3 µS/cm against mean value of 432.4 ± 204.5 µs/cm for south India soils. In conclusion, this study proclaims that higher level of bioactive phytochemical, mahanine in MK leaves depending upon geographical location, weather suitability and soil’s physiochemical and microbial parameters of its cultivation sites.
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spelling pubmed-76759832020-11-19 Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability Kandimalla, Raghuram Das, Momita Barge, Sagar R. Sarma, Partha Pratim Koiri, Dibya Jyoti Devi, Arundhuti Karki, Arjun Kumar Kumar, Anil Devi, Rajlakshmi Pal, Bikas C. Talukdar, Narayan C. Samanta, Suman Kumar Sci Rep Article Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital bioactive phytochemical, mahanine in the MK leaves from different geographical locations of varying soil properties and weather parameters was determined. Accordingly, MK leaves and soil samples around the plant base in quintuplicate from each site across five states of India at similar time point were collected. Mahanine content was determined and compared among samples from different regions. The quantitative analysis data comprised that MK-leaves of southern part of India contains highest amount of mahanine, which is 16.9 times higher than that of MK-leaves of north-eastern part of India (which measured as the lowest). The results suggested that pH, conductivity and bacterial populations of the soil samples were positively correlated with mahanine content in the MK-leaves. For examples, the average soil pH of the southern India sites was in basic range (8.8 ± 0.6); whereas that of the north-east India sites was in slightly acidic ranges (6.1 ± 0.5) and mean soil conductivity value for the north east India soils was 78.3 ± 16.3 µS/cm against mean value of 432.4 ± 204.5 µs/cm for south India soils. In conclusion, this study proclaims that higher level of bioactive phytochemical, mahanine in MK leaves depending upon geographical location, weather suitability and soil’s physiochemical and microbial parameters of its cultivation sites. Nature Publishing Group UK 2020-11-18 /pmc/articles/PMC7675983/ /pubmed/33208840 http://dx.doi.org/10.1038/s41598-020-77113-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kandimalla, Raghuram
Das, Momita
Barge, Sagar R.
Sarma, Partha Pratim
Koiri, Dibya Jyoti
Devi, Arundhuti
Karki, Arjun Kumar
Kumar, Anil
Devi, Rajlakshmi
Pal, Bikas C.
Talukdar, Narayan C.
Samanta, Suman Kumar
Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability
title Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability
title_full Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability
title_fullStr Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability
title_full_unstemmed Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability
title_short Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability
title_sort variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in murraya koenigii, conditional on soil physicochemistry and weather suitability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675983/
https://www.ncbi.nlm.nih.gov/pubmed/33208840
http://dx.doi.org/10.1038/s41598-020-77113-y
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