Interleukin‐12B gene rs6887695 and rs2288831 polymorphisms are associated with an increased risk of ulcerative colitis development in Chinese Han population: A case‐control study

BACKGROUND: The association of the interleukin (IL)‐12B gene rs6887695 and rs2288831 polymorphisms with ulcerative colitis (UC) risk has been extensively investigated, but results are conflicting. In this study, we investigated potential link between the IL‐12B gene rs6887695 and rs2288831 polymorphisms and UC development in Chinese Han population. MATERIAL AND METHODS: Genotyping was performed in 367 patients and 456 controls through polymerase chain reaction‐restriction fragment length polymorphism analysis. Plasma levels of IL‐12B were tested using an enzyme‐linked immunosorbent assay. RESULTS: We found that the IL‐12B gene rs6887695 and rs2288831 polymorphisms were related to a significantly increased risk of UC. Subgroup analyses revealed significant associations of the IL‐12B gene rs6887695 and rs2288831 polymorphisms with UC risk among females, consumers of alcohol, and those aged <40 years. Additionally, the rs6887695 and rs2288831 polymorphisms were associated with lesion location and UC treatment. Last, we found that these two polymorphisms were associated with IL‐12B levels. CONCLUSIONS: The IL‐12B gene rs6887695 and rs2288831 polymorphisms were associated with a higher risk, and the clinical characteristics, of UC.