Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen

MYC oncoprotein is a multifunctional transcription factor that regulates the expression of a large number of genes involved in cellular growth, proliferation and metabolism. Altered MYC protein level lead to cellular transformation and tumorigenesis. MYC is deregulated in > 50% of human cancers,...

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Detalles Bibliográficos
Autores principales: Schukur, Lina, Zimmermann, Tamara, Niewoehner, Ole, Kerr, Grainne, Gleim, Scott, Bauer-Probst, Beatrice, Knapp, Britta, Galli, Giorgio G., Liang, Xiaoyou, Mendiola, Angelica, Reece-Hoyes, John, Rapti, Melivoia, Barbosa, Ines, Reschke, Markus, Radimerski, Thomas, Thoma, Claudio R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676242/
https://www.ncbi.nlm.nih.gov/pubmed/33208877
http://dx.doi.org/10.1038/s41598-020-76960-z

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