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K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice

Obesity and its associated metabolic disorders are increasingly impacting public health worldwide. Sphingosine kinase 1 (Sphk1) is a critical enzyme in sphingolipid metabolism that has been implicated in various metabolic syndromes. In this study, we developed a mouse model constitutively expressing...

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Detalles Bibliográficos
Autores principales:	Xie, Jing, Shao, Yong, Liu, Jin, Cui, Meilan, Xiao, Xiuxiao, Gong, Jingbo, Xue, Binghua, Zhang, Qunwei, Hu, Xianwen, Duan, Haifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676274/ https://www.ncbi.nlm.nih.gov/pubmed/33208918 http://dx.doi.org/10.1038/s41598-020-77096-w

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