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Investigation into the Formation of Impurities during the Optimization of Brigatinib
[Image: see text] During the process development of brigatinib, we have made an unusual observation about some impurities. Detailed investigation has led to the conclusion that impurity A is formed via the raw material 2 oxidation, impurity B is formed via the pyrolysis of DMF, impurity C is formed...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676304/ https://www.ncbi.nlm.nih.gov/pubmed/33225157 http://dx.doi.org/10.1021/acsomega.0c03816 |