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Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report
We report a second case of methemoglobinemia and non-autoimmune hemolytic anemia after contracting the SARS-CoV-2 infection in the absence of an identifiable eliciting drug. A 35-year old male without previous known comorbidities was admitted after he was diagnosed with the COVID-19 infection and ha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676365/ https://www.ncbi.nlm.nih.gov/pubmed/33235826 http://dx.doi.org/10.1016/j.idcr.2020.e01013 |
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author | Lopes, Desirée Verde Lazar Neto, Felippe Marques, Lais C. Lima, Rodrigo B.O. Brandão, Antonio Adolfo Guerra Soares |
author_facet | Lopes, Desirée Verde Lazar Neto, Felippe Marques, Lais C. Lima, Rodrigo B.O. Brandão, Antonio Adolfo Guerra Soares |
author_sort | Lopes, Desirée Verde |
collection | PubMed |
description | We report a second case of methemoglobinemia and non-autoimmune hemolytic anemia after contracting the SARS-CoV-2 infection in the absence of an identifiable eliciting drug. A 35-year old male without previous known comorbidities was admitted after he was diagnosed with the COVID-19 infection and had large pulmonary involvement. Seven days later, he desaturated but was without any signs of respiratory distress. A check of arterial blood gas revealed normal partial pressure of oxygen and follow-up tests confirmed a methemoglobinemia diagnosis. Over the next few days, hemolysis was established after decreased levels of hemoglobin and increased levels of indirect bilirubin and lactate dehydrogenase. A hemolytic anemia investigation panel came back normal, including G6PD. A second G6PD test was ordered at the 5-month follow-up appointment and revealed decreased levels. Clinicians should thus be aware of possible false negative tests when testing for G6PD during hemolytic crisis. In addition, whether the COVID-19 infection alone would be responsible for this chain of events remains a challenging question. |
format | Online Article Text |
id | pubmed-7676365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-76763652020-11-20 Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report Lopes, Desirée Verde Lazar Neto, Felippe Marques, Lais C. Lima, Rodrigo B.O. Brandão, Antonio Adolfo Guerra Soares IDCases Case Report We report a second case of methemoglobinemia and non-autoimmune hemolytic anemia after contracting the SARS-CoV-2 infection in the absence of an identifiable eliciting drug. A 35-year old male without previous known comorbidities was admitted after he was diagnosed with the COVID-19 infection and had large pulmonary involvement. Seven days later, he desaturated but was without any signs of respiratory distress. A check of arterial blood gas revealed normal partial pressure of oxygen and follow-up tests confirmed a methemoglobinemia diagnosis. Over the next few days, hemolysis was established after decreased levels of hemoglobin and increased levels of indirect bilirubin and lactate dehydrogenase. A hemolytic anemia investigation panel came back normal, including G6PD. A second G6PD test was ordered at the 5-month follow-up appointment and revealed decreased levels. Clinicians should thus be aware of possible false negative tests when testing for G6PD during hemolytic crisis. In addition, whether the COVID-19 infection alone would be responsible for this chain of events remains a challenging question. Elsevier 2020-11-19 /pmc/articles/PMC7676365/ /pubmed/33235826 http://dx.doi.org/10.1016/j.idcr.2020.e01013 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Lopes, Desirée Verde Lazar Neto, Felippe Marques, Lais C. Lima, Rodrigo B.O. Brandão, Antonio Adolfo Guerra Soares Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report |
title | Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report |
title_full | Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report |
title_fullStr | Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report |
title_full_unstemmed | Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report |
title_short | Methemoglobinemia and hemolytic anemia after COVID-19 infection without identifiable eliciting drug: A case-report |
title_sort | methemoglobinemia and hemolytic anemia after covid-19 infection without identifiable eliciting drug: a case-report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676365/ https://www.ncbi.nlm.nih.gov/pubmed/33235826 http://dx.doi.org/10.1016/j.idcr.2020.e01013 |
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