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Association of elevated inflammatory markers and severe COVID-19: A meta-analysis

Our study aimed to assess the existing evidence on whether severe coronavirus disease 2019 (COVID-19) is associated with elevated inflammatory markers. The PubMed, Embase, Web of Science, Scopus, Chinese National Knowledge Infrastructure, WanFang, and China Science and Technology Journal databases w...

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Detalles Bibliográficos
Autores principales: Ji, Pan, Zhu, Jieyun, Zhong, Zhimei, Li, Hongyuan, Pang, Jielong, Li, Bocheng, Zhang, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676531/
https://www.ncbi.nlm.nih.gov/pubmed/33217868
http://dx.doi.org/10.1097/MD.0000000000023315
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author Ji, Pan
Zhu, Jieyun
Zhong, Zhimei
Li, Hongyuan
Pang, Jielong
Li, Bocheng
Zhang, Jianfeng
author_facet Ji, Pan
Zhu, Jieyun
Zhong, Zhimei
Li, Hongyuan
Pang, Jielong
Li, Bocheng
Zhang, Jianfeng
author_sort Ji, Pan
collection PubMed
description Our study aimed to assess the existing evidence on whether severe coronavirus disease 2019 (COVID-19) is associated with elevated inflammatory markers. The PubMed, Embase, Web of Science, Scopus, Chinese National Knowledge Infrastructure, WanFang, and China Science and Technology Journal databases were searched to identify studies published between January 1 and April 21, 2020 that assayed inflammatory markers in COVID-19 patients. Three reviewers independently examined the literature, extracted relevant data, and assessed the risk of publication bias before including the meta-analysis studies. Fifty-six studies involving 8719 COVID-19 patients were identified. Meta-analysis showed that patients with severe disease showed elevated levels of white blood cell count (WMD: 1.15, 95% CI: 0.78–1.52), C-reactive protein (WMD: 38.85, 95% CI: 31.19–46.52), procalcitonin (WMD: 0.08, 95% CI: 0.06–0.11), erythrocyte sedimentation rate (WMD: 10.15, 95% CI: 5.03–15.46), interleukin-6 (WMD: 23.87, 95% CI: 15.95–31.78), and interleukin-10 (WMD: 2.12, 95% CI: 1.97–2.28). Similarly, COVID-19 patients who died during follow-up showed significantly higher levels of white blood cell count (WMD: 4.11, 95% CI: 3.25–4.97), C-reactive protein (WMD: 74.18, 95% CI: 56.63–91.73), procalcitonin (WMD: 0.26, 95% CI: 0.11–0.42), erythrocyte sedimentation rate (WMD: 10.94, 95% CI: 4.79–17.09), and interleukin-6 (WMD: 59.88, 95% CI: 19.46–100.30) than survivors. Severe COVID-19 is associated with higher levels of inflammatory markers than a mild disease, so tracking these markers may allow early identification or even prediction of disease progression.
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spelling pubmed-76765312020-11-24 Association of elevated inflammatory markers and severe COVID-19: A meta-analysis Ji, Pan Zhu, Jieyun Zhong, Zhimei Li, Hongyuan Pang, Jielong Li, Bocheng Zhang, Jianfeng Medicine (Baltimore) 4400 Our study aimed to assess the existing evidence on whether severe coronavirus disease 2019 (COVID-19) is associated with elevated inflammatory markers. The PubMed, Embase, Web of Science, Scopus, Chinese National Knowledge Infrastructure, WanFang, and China Science and Technology Journal databases were searched to identify studies published between January 1 and April 21, 2020 that assayed inflammatory markers in COVID-19 patients. Three reviewers independently examined the literature, extracted relevant data, and assessed the risk of publication bias before including the meta-analysis studies. Fifty-six studies involving 8719 COVID-19 patients were identified. Meta-analysis showed that patients with severe disease showed elevated levels of white blood cell count (WMD: 1.15, 95% CI: 0.78–1.52), C-reactive protein (WMD: 38.85, 95% CI: 31.19–46.52), procalcitonin (WMD: 0.08, 95% CI: 0.06–0.11), erythrocyte sedimentation rate (WMD: 10.15, 95% CI: 5.03–15.46), interleukin-6 (WMD: 23.87, 95% CI: 15.95–31.78), and interleukin-10 (WMD: 2.12, 95% CI: 1.97–2.28). Similarly, COVID-19 patients who died during follow-up showed significantly higher levels of white blood cell count (WMD: 4.11, 95% CI: 3.25–4.97), C-reactive protein (WMD: 74.18, 95% CI: 56.63–91.73), procalcitonin (WMD: 0.26, 95% CI: 0.11–0.42), erythrocyte sedimentation rate (WMD: 10.94, 95% CI: 4.79–17.09), and interleukin-6 (WMD: 59.88, 95% CI: 19.46–100.30) than survivors. Severe COVID-19 is associated with higher levels of inflammatory markers than a mild disease, so tracking these markers may allow early identification or even prediction of disease progression. Lippincott Williams & Wilkins 2020-11-20 /pmc/articles/PMC7676531/ /pubmed/33217868 http://dx.doi.org/10.1097/MD.0000000000023315 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4400
Ji, Pan
Zhu, Jieyun
Zhong, Zhimei
Li, Hongyuan
Pang, Jielong
Li, Bocheng
Zhang, Jianfeng
Association of elevated inflammatory markers and severe COVID-19: A meta-analysis
title Association of elevated inflammatory markers and severe COVID-19: A meta-analysis
title_full Association of elevated inflammatory markers and severe COVID-19: A meta-analysis
title_fullStr Association of elevated inflammatory markers and severe COVID-19: A meta-analysis
title_full_unstemmed Association of elevated inflammatory markers and severe COVID-19: A meta-analysis
title_short Association of elevated inflammatory markers and severe COVID-19: A meta-analysis
title_sort association of elevated inflammatory markers and severe covid-19: a meta-analysis
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676531/
https://www.ncbi.nlm.nih.gov/pubmed/33217868
http://dx.doi.org/10.1097/MD.0000000000023315
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