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Kemeny-based testing for COVID-19

Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first wave of the COVID-19 virus. Contact tracing apps give the unprecedented possibility to reconstruct graphs of daily contacts, so the question is: who should be test...

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Autores principales: Yilmaz, Serife, Dudkina, Ekaterina, Bin, Michelangelo, Crisostomi, Emanuele, Ferraro, Pietro, Murray-Smith, Roderick, Parisini, Thomas, Stone, Lewi, Shorten, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676669/
https://www.ncbi.nlm.nih.gov/pubmed/33211725
http://dx.doi.org/10.1371/journal.pone.0242401
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author Yilmaz, Serife
Dudkina, Ekaterina
Bin, Michelangelo
Crisostomi, Emanuele
Ferraro, Pietro
Murray-Smith, Roderick
Parisini, Thomas
Stone, Lewi
Shorten, Robert
author_facet Yilmaz, Serife
Dudkina, Ekaterina
Bin, Michelangelo
Crisostomi, Emanuele
Ferraro, Pietro
Murray-Smith, Roderick
Parisini, Thomas
Stone, Lewi
Shorten, Robert
author_sort Yilmaz, Serife
collection PubMed
description Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first wave of the COVID-19 virus. Contact tracing apps give the unprecedented possibility to reconstruct graphs of daily contacts, so the question is: who should be tested? As human contact networks are known to exhibit community structure, in this paper we show that the Kemeny constant of a graph can be used to identify and analyze bridges between communities in a graph. Our ‘Kemeny indicator’ is the value of the Kemeny constant in the new graph that is obtained when a node is removed from the original graph. We show that testing individuals who are associated with large values of the Kemeny indicator can help in efficiently intercepting new virus outbreaks, when they are still in their early stage. Extensive simulations provide promising results in early identification and in blocking the possible ‘super-spreaders’ links that transmit disease between different communities.
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spelling pubmed-76766692020-12-02 Kemeny-based testing for COVID-19 Yilmaz, Serife Dudkina, Ekaterina Bin, Michelangelo Crisostomi, Emanuele Ferraro, Pietro Murray-Smith, Roderick Parisini, Thomas Stone, Lewi Shorten, Robert PLoS One Research Article Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first wave of the COVID-19 virus. Contact tracing apps give the unprecedented possibility to reconstruct graphs of daily contacts, so the question is: who should be tested? As human contact networks are known to exhibit community structure, in this paper we show that the Kemeny constant of a graph can be used to identify and analyze bridges between communities in a graph. Our ‘Kemeny indicator’ is the value of the Kemeny constant in the new graph that is obtained when a node is removed from the original graph. We show that testing individuals who are associated with large values of the Kemeny indicator can help in efficiently intercepting new virus outbreaks, when they are still in their early stage. Extensive simulations provide promising results in early identification and in blocking the possible ‘super-spreaders’ links that transmit disease between different communities. Public Library of Science 2020-11-19 /pmc/articles/PMC7676669/ /pubmed/33211725 http://dx.doi.org/10.1371/journal.pone.0242401 Text en © 2020 Yilmaz et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yilmaz, Serife
Dudkina, Ekaterina
Bin, Michelangelo
Crisostomi, Emanuele
Ferraro, Pietro
Murray-Smith, Roderick
Parisini, Thomas
Stone, Lewi
Shorten, Robert
Kemeny-based testing for COVID-19
title Kemeny-based testing for COVID-19
title_full Kemeny-based testing for COVID-19
title_fullStr Kemeny-based testing for COVID-19
title_full_unstemmed Kemeny-based testing for COVID-19
title_short Kemeny-based testing for COVID-19
title_sort kemeny-based testing for covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676669/
https://www.ncbi.nlm.nih.gov/pubmed/33211725
http://dx.doi.org/10.1371/journal.pone.0242401
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