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Kemeny-based testing for COVID-19
Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first wave of the COVID-19 virus. Contact tracing apps give the unprecedented possibility to reconstruct graphs of daily contacts, so the question is: who should be test...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676669/ https://www.ncbi.nlm.nih.gov/pubmed/33211725 http://dx.doi.org/10.1371/journal.pone.0242401 |
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author | Yilmaz, Serife Dudkina, Ekaterina Bin, Michelangelo Crisostomi, Emanuele Ferraro, Pietro Murray-Smith, Roderick Parisini, Thomas Stone, Lewi Shorten, Robert |
author_facet | Yilmaz, Serife Dudkina, Ekaterina Bin, Michelangelo Crisostomi, Emanuele Ferraro, Pietro Murray-Smith, Roderick Parisini, Thomas Stone, Lewi Shorten, Robert |
author_sort | Yilmaz, Serife |
collection | PubMed |
description | Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first wave of the COVID-19 virus. Contact tracing apps give the unprecedented possibility to reconstruct graphs of daily contacts, so the question is: who should be tested? As human contact networks are known to exhibit community structure, in this paper we show that the Kemeny constant of a graph can be used to identify and analyze bridges between communities in a graph. Our ‘Kemeny indicator’ is the value of the Kemeny constant in the new graph that is obtained when a node is removed from the original graph. We show that testing individuals who are associated with large values of the Kemeny indicator can help in efficiently intercepting new virus outbreaks, when they are still in their early stage. Extensive simulations provide promising results in early identification and in blocking the possible ‘super-spreaders’ links that transmit disease between different communities. |
format | Online Article Text |
id | pubmed-7676669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76766692020-12-02 Kemeny-based testing for COVID-19 Yilmaz, Serife Dudkina, Ekaterina Bin, Michelangelo Crisostomi, Emanuele Ferraro, Pietro Murray-Smith, Roderick Parisini, Thomas Stone, Lewi Shorten, Robert PLoS One Research Article Testing, tracking and tracing abilities have been identified as pivotal in helping countries to safely reopen activities after the first wave of the COVID-19 virus. Contact tracing apps give the unprecedented possibility to reconstruct graphs of daily contacts, so the question is: who should be tested? As human contact networks are known to exhibit community structure, in this paper we show that the Kemeny constant of a graph can be used to identify and analyze bridges between communities in a graph. Our ‘Kemeny indicator’ is the value of the Kemeny constant in the new graph that is obtained when a node is removed from the original graph. We show that testing individuals who are associated with large values of the Kemeny indicator can help in efficiently intercepting new virus outbreaks, when they are still in their early stage. Extensive simulations provide promising results in early identification and in blocking the possible ‘super-spreaders’ links that transmit disease between different communities. Public Library of Science 2020-11-19 /pmc/articles/PMC7676669/ /pubmed/33211725 http://dx.doi.org/10.1371/journal.pone.0242401 Text en © 2020 Yilmaz et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yilmaz, Serife Dudkina, Ekaterina Bin, Michelangelo Crisostomi, Emanuele Ferraro, Pietro Murray-Smith, Roderick Parisini, Thomas Stone, Lewi Shorten, Robert Kemeny-based testing for COVID-19 |
title | Kemeny-based testing for COVID-19 |
title_full | Kemeny-based testing for COVID-19 |
title_fullStr | Kemeny-based testing for COVID-19 |
title_full_unstemmed | Kemeny-based testing for COVID-19 |
title_short | Kemeny-based testing for COVID-19 |
title_sort | kemeny-based testing for covid-19 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676669/ https://www.ncbi.nlm.nih.gov/pubmed/33211725 http://dx.doi.org/10.1371/journal.pone.0242401 |
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