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Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis
BACKGROUND: Major depression disorder (MDD) is a severe health threat characterized by persistent depression, loss of interests, lack of initiative, and even suicidal tendencies. Traditional Chinese medicine (TCM) is well tolerated and effective in treating adult MDD. However, research on the evalua...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676811/ https://www.ncbi.nlm.nih.gov/pubmed/33217832 http://dx.doi.org/10.1097/MD.0000000000023199 |
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author | Shao, Yuze Wang, Kai Jiang, Zhenyuan Yu, Xiaowen An, Wenrong Han, Yue Wang, Zhonglin |
author_facet | Shao, Yuze Wang, Kai Jiang, Zhenyuan Yu, Xiaowen An, Wenrong Han, Yue Wang, Zhonglin |
author_sort | Shao, Yuze |
collection | PubMed |
description | BACKGROUND: Major depression disorder (MDD) is a severe health threat characterized by persistent depression, loss of interests, lack of initiative, and even suicidal tendencies. Traditional Chinese medicine (TCM) is well tolerated and effective in treating adult MDD. However, research on the evaluation of efficacy and acceptability of different TCM strategies for adult MDD is insufficient. Consequently, it is high time to evaluate the efficacy of TCM strategies for adult MDD. Meanwhile, the acceptability of different TCM strategies is worth exploring. METHODS: Comprehensively and systematically retrieve the literature in PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure Database (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), and Chinese BioMedical Literature Database (CBM). The literature search will focus on randomized controlled trials (RCTs) with TCM in adult MDD. Two reviewers will search the literature and extract relevant data back-to-back. Once mismatched outcomes appear, arbitration will be conducted by a third reviewer. Based on the Bayesian framework, data analysis is carried out with STATA and WinBUGS software. Heterogeneity, transitivity, consistency test, bias risk assessment, subgroup and sensitivity analysis, evidence quality evaluation will be performed accordingly. RESULTS: The efficacy and acceptability of different TCM strategies for adults with MDD will be compared and sorted. CONCLUSION: The study will facilitate the treatment options of adults MDD according to the supporting evidence. INPLASY REGISTRATION NUMBER: INPLASY2020100028. |
format | Online Article Text |
id | pubmed-7676811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-76768112020-11-24 Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis Shao, Yuze Wang, Kai Jiang, Zhenyuan Yu, Xiaowen An, Wenrong Han, Yue Wang, Zhonglin Medicine (Baltimore) 5300 BACKGROUND: Major depression disorder (MDD) is a severe health threat characterized by persistent depression, loss of interests, lack of initiative, and even suicidal tendencies. Traditional Chinese medicine (TCM) is well tolerated and effective in treating adult MDD. However, research on the evaluation of efficacy and acceptability of different TCM strategies for adult MDD is insufficient. Consequently, it is high time to evaluate the efficacy of TCM strategies for adult MDD. Meanwhile, the acceptability of different TCM strategies is worth exploring. METHODS: Comprehensively and systematically retrieve the literature in PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure Database (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), and Chinese BioMedical Literature Database (CBM). The literature search will focus on randomized controlled trials (RCTs) with TCM in adult MDD. Two reviewers will search the literature and extract relevant data back-to-back. Once mismatched outcomes appear, arbitration will be conducted by a third reviewer. Based on the Bayesian framework, data analysis is carried out with STATA and WinBUGS software. Heterogeneity, transitivity, consistency test, bias risk assessment, subgroup and sensitivity analysis, evidence quality evaluation will be performed accordingly. RESULTS: The efficacy and acceptability of different TCM strategies for adults with MDD will be compared and sorted. CONCLUSION: The study will facilitate the treatment options of adults MDD according to the supporting evidence. INPLASY REGISTRATION NUMBER: INPLASY2020100028. Lippincott Williams & Wilkins 2020-11-20 /pmc/articles/PMC7676811/ /pubmed/33217832 http://dx.doi.org/10.1097/MD.0000000000023199 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5300 Shao, Yuze Wang, Kai Jiang, Zhenyuan Yu, Xiaowen An, Wenrong Han, Yue Wang, Zhonglin Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis |
title | Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis |
title_full | Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis |
title_fullStr | Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis |
title_full_unstemmed | Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis |
title_short | Comparative efficacy and acceptability of traditional Chinese medicine for adult major depression: A protocol for network meta-analysis |
title_sort | comparative efficacy and acceptability of traditional chinese medicine for adult major depression: a protocol for network meta-analysis |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676811/ https://www.ncbi.nlm.nih.gov/pubmed/33217832 http://dx.doi.org/10.1097/MD.0000000000023199 |
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