Cargando…

Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia

OBJECTIVE: Neuregulin 1 (NRG 1) is a member of the epidermal growth factor (EGF) family and is believed to play an important role in neuroplasticity. However, the relationship between NRG 1 and vascular dementia (VaD) is poorly understood. The purpose of this study is to explore the correlation betw...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiaoling, Zhang, Fengyu, Ma, Weibin, Feng, Depeng, Zhang, Jingjing, Xu, Jialei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676920/
https://www.ncbi.nlm.nih.gov/pubmed/33274218
http://dx.doi.org/10.1155/2020/6683747
_version_ 1783611873203060736
author Wang, Xiaoling
Zhang, Fengyu
Ma, Weibin
Feng, Depeng
Zhang, Jingjing
Xu, Jialei
author_facet Wang, Xiaoling
Zhang, Fengyu
Ma, Weibin
Feng, Depeng
Zhang, Jingjing
Xu, Jialei
author_sort Wang, Xiaoling
collection PubMed
description OBJECTIVE: Neuregulin 1 (NRG 1) is a member of the epidermal growth factor (EGF) family and is believed to play an important role in neuroplasticity. However, the relationship between NRG 1 and vascular dementia (VaD) is poorly understood. The purpose of this study is to explore the correlation between neuregulin 1 and VaD. Patients and Methods. From October 2018 to September 2020, 93 VaD patients and 79 control populations who attended Liaocheng People's Hospital were included in the study. Baseline characteristics including age, gender, years of education, HDL, LDL, FBG, SBP, and DBP are collected. At the same time, peripheral blood was collected, and the concentration of serum NRG 1 was detected by enzyme-linked immunosorbent assay (ELISA). All research subjects received professional cognitive function assessment. RESULTS: A total of 93 VaD patients and 79 controls were enrolled. There was no significant difference in age, gender, years of education, HDL, LDL, FBG, SBP, and DBP between the two groups (p > 0.05). However, compared with the control group, VaD patients have lower MoCA and higher serum NRG 1 levels, and the difference is statistically significant (p < 0.001). The correlation analysis of MoCA and baseline characteristics showed that the MoCA score in VaD was significantly negatively correlated with serum NRG 1 (r = −0.374, p = 0.036). The results of multivariate regression showed that the MoCA score of VaD patients was only associated with NRG 1 (β = 0.258, p = 0.012). CONCLUSIONS: The concentration of serum NRG 1 in VaD patients is significantly increased, which may be an independent risk factor for cognitive impairment in VaD patients.
format Online
Article
Text
id pubmed-7676920
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-76769202020-12-02 Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia Wang, Xiaoling Zhang, Fengyu Ma, Weibin Feng, Depeng Zhang, Jingjing Xu, Jialei Biomed Res Int Research Article OBJECTIVE: Neuregulin 1 (NRG 1) is a member of the epidermal growth factor (EGF) family and is believed to play an important role in neuroplasticity. However, the relationship between NRG 1 and vascular dementia (VaD) is poorly understood. The purpose of this study is to explore the correlation between neuregulin 1 and VaD. Patients and Methods. From October 2018 to September 2020, 93 VaD patients and 79 control populations who attended Liaocheng People's Hospital were included in the study. Baseline characteristics including age, gender, years of education, HDL, LDL, FBG, SBP, and DBP are collected. At the same time, peripheral blood was collected, and the concentration of serum NRG 1 was detected by enzyme-linked immunosorbent assay (ELISA). All research subjects received professional cognitive function assessment. RESULTS: A total of 93 VaD patients and 79 controls were enrolled. There was no significant difference in age, gender, years of education, HDL, LDL, FBG, SBP, and DBP between the two groups (p > 0.05). However, compared with the control group, VaD patients have lower MoCA and higher serum NRG 1 levels, and the difference is statistically significant (p < 0.001). The correlation analysis of MoCA and baseline characteristics showed that the MoCA score in VaD was significantly negatively correlated with serum NRG 1 (r = −0.374, p = 0.036). The results of multivariate regression showed that the MoCA score of VaD patients was only associated with NRG 1 (β = 0.258, p = 0.012). CONCLUSIONS: The concentration of serum NRG 1 in VaD patients is significantly increased, which may be an independent risk factor for cognitive impairment in VaD patients. Hindawi 2020-11-12 /pmc/articles/PMC7676920/ /pubmed/33274218 http://dx.doi.org/10.1155/2020/6683747 Text en Copyright © 2020 Xiaoling Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Xiaoling
Zhang, Fengyu
Ma, Weibin
Feng, Depeng
Zhang, Jingjing
Xu, Jialei
Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia
title Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia
title_full Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia
title_fullStr Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia
title_full_unstemmed Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia
title_short Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia
title_sort increased levels of serum neuregulin 1 associated with cognitive impairment in vascular dementia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676920/
https://www.ncbi.nlm.nih.gov/pubmed/33274218
http://dx.doi.org/10.1155/2020/6683747
work_keys_str_mv AT wangxiaoling increasedlevelsofserumneuregulin1associatedwithcognitiveimpairmentinvasculardementia
AT zhangfengyu increasedlevelsofserumneuregulin1associatedwithcognitiveimpairmentinvasculardementia
AT maweibin increasedlevelsofserumneuregulin1associatedwithcognitiveimpairmentinvasculardementia
AT fengdepeng increasedlevelsofserumneuregulin1associatedwithcognitiveimpairmentinvasculardementia
AT zhangjingjing increasedlevelsofserumneuregulin1associatedwithcognitiveimpairmentinvasculardementia
AT xujialei increasedlevelsofserumneuregulin1associatedwithcognitiveimpairmentinvasculardementia