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Early weaning augments the spontaneous release of dopamine in the amygdala but not the prefrontal cortex: an in vivo microdialysis study of male rats
Our early weaning schedule was associated with the emergence of trait anxiety in male rodents performing an elevated plus maze but not an open-field test. We previously reported that early weaning weakened excitatory neurotransmission to the amygdala from the prefrontal cortex, where the mesocortico...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677083/ https://www.ncbi.nlm.nih.gov/pubmed/32350170 http://dx.doi.org/10.1538/expanim.20-0015 |
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author | Takita, Masatoshi Kikusui, Takefumi |
author_facet | Takita, Masatoshi Kikusui, Takefumi |
author_sort | Takita, Masatoshi |
collection | PubMed |
description | Our early weaning schedule was associated with the emergence of trait anxiety in male rodents performing an elevated plus maze but not an open-field test. We previously reported that early weaning weakened excitatory neurotransmission to the amygdala from the prefrontal cortex, where the mesocorticolimbic dopaminergic (DAergic) fiber terminates on each. In this study, we investigated DAergic transmission in both these brain regions. The extracellular levels of amygdalar DA in adulthood were two times higher in rats weaned at 16 days compared to those weaned at 30 days in both the home cage and the open-field. This difference in extracellular DA levels was not apparent in the prefrontal cortex. The concurrently measured locomotor and rearing behaviors did not vary according to the weaning period and the probe-implanted region, respectively. These results suggest that the effects of early weaning on DA tone appear to be specific to the amygdala and do not represent ubiquitous upregulation as these changes were not observed in the prefrontal cortex. |
format | Online Article Text |
id | pubmed-7677083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76770832020-11-24 Early weaning augments the spontaneous release of dopamine in the amygdala but not the prefrontal cortex: an in vivo microdialysis study of male rats Takita, Masatoshi Kikusui, Takefumi Exp Anim Original Our early weaning schedule was associated with the emergence of trait anxiety in male rodents performing an elevated plus maze but not an open-field test. We previously reported that early weaning weakened excitatory neurotransmission to the amygdala from the prefrontal cortex, where the mesocorticolimbic dopaminergic (DAergic) fiber terminates on each. In this study, we investigated DAergic transmission in both these brain regions. The extracellular levels of amygdalar DA in adulthood were two times higher in rats weaned at 16 days compared to those weaned at 30 days in both the home cage and the open-field. This difference in extracellular DA levels was not apparent in the prefrontal cortex. The concurrently measured locomotor and rearing behaviors did not vary according to the weaning period and the probe-implanted region, respectively. These results suggest that the effects of early weaning on DA tone appear to be specific to the amygdala and do not represent ubiquitous upregulation as these changes were not observed in the prefrontal cortex. Japanese Association for Laboratory Animal Science 2020-04-28 2020 /pmc/articles/PMC7677083/ /pubmed/32350170 http://dx.doi.org/10.1538/expanim.20-0015 Text en ©2020 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Original Takita, Masatoshi Kikusui, Takefumi Early weaning augments the spontaneous release of dopamine in the amygdala but not the prefrontal cortex: an in vivo microdialysis study of male rats |
title | Early weaning augments the spontaneous release of dopamine in the amygdala
but not the prefrontal cortex: an in vivo microdialysis study of male
rats |
title_full | Early weaning augments the spontaneous release of dopamine in the amygdala
but not the prefrontal cortex: an in vivo microdialysis study of male
rats |
title_fullStr | Early weaning augments the spontaneous release of dopamine in the amygdala
but not the prefrontal cortex: an in vivo microdialysis study of male
rats |
title_full_unstemmed | Early weaning augments the spontaneous release of dopamine in the amygdala
but not the prefrontal cortex: an in vivo microdialysis study of male
rats |
title_short | Early weaning augments the spontaneous release of dopamine in the amygdala
but not the prefrontal cortex: an in vivo microdialysis study of male
rats |
title_sort | early weaning augments the spontaneous release of dopamine in the amygdala
but not the prefrontal cortex: an in vivo microdialysis study of male
rats |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677083/ https://www.ncbi.nlm.nih.gov/pubmed/32350170 http://dx.doi.org/10.1538/expanim.20-0015 |
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