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More than a Genetic Code: Epigenetics of Lung Fibrosis

At the end of the last century, genetic studies reported that genetic information is not transmitted solely by DNA, but is also transmitted by other mechanisms, named as epigenetics. The well-described epigenetic mechanisms include DNA methylation, biochemical modifications of histones, and microRNA...

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Autores principales: Bartczak, Krystian, Białas, Adam J., Kotecki, Mateusz J., Górski, Paweł, Piotrowski, Wojciech J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677145/
https://www.ncbi.nlm.nih.gov/pubmed/32926347
http://dx.doi.org/10.1007/s40291-020-00490-7
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author Bartczak, Krystian
Białas, Adam J.
Kotecki, Mateusz J.
Górski, Paweł
Piotrowski, Wojciech J.
author_facet Bartczak, Krystian
Białas, Adam J.
Kotecki, Mateusz J.
Górski, Paweł
Piotrowski, Wojciech J.
author_sort Bartczak, Krystian
collection PubMed
description At the end of the last century, genetic studies reported that genetic information is not transmitted solely by DNA, but is also transmitted by other mechanisms, named as epigenetics. The well-described epigenetic mechanisms include DNA methylation, biochemical modifications of histones, and microRNAs. The role of altered epigenetics in the biology of various fibrotic diseases is well-established, and recent advances demonstrate its importance in the pathogenesis of pulmonary fibrosis—predominantly referring to idiopathic pulmonary fibrosis, the most lethal of the interstitial lung diseases. The deficiency in effective medications suggests an urgent need to better understand the underlying pathobiology. This review summarizes the current knowledge concerning epigenetic changes in pulmonary fibrosis and associations of these changes with several cellular pathways of known significance in its pathogenesis. It also designates the most promising substances for further research that may bring us closer to new therapeutic options.
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spelling pubmed-76771452020-11-30 More than a Genetic Code: Epigenetics of Lung Fibrosis Bartczak, Krystian Białas, Adam J. Kotecki, Mateusz J. Górski, Paweł Piotrowski, Wojciech J. Mol Diagn Ther Review Article At the end of the last century, genetic studies reported that genetic information is not transmitted solely by DNA, but is also transmitted by other mechanisms, named as epigenetics. The well-described epigenetic mechanisms include DNA methylation, biochemical modifications of histones, and microRNAs. The role of altered epigenetics in the biology of various fibrotic diseases is well-established, and recent advances demonstrate its importance in the pathogenesis of pulmonary fibrosis—predominantly referring to idiopathic pulmonary fibrosis, the most lethal of the interstitial lung diseases. The deficiency in effective medications suggests an urgent need to better understand the underlying pathobiology. This review summarizes the current knowledge concerning epigenetic changes in pulmonary fibrosis and associations of these changes with several cellular pathways of known significance in its pathogenesis. It also designates the most promising substances for further research that may bring us closer to new therapeutic options. Springer International Publishing 2020-09-14 2020 /pmc/articles/PMC7677145/ /pubmed/32926347 http://dx.doi.org/10.1007/s40291-020-00490-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review Article
Bartczak, Krystian
Białas, Adam J.
Kotecki, Mateusz J.
Górski, Paweł
Piotrowski, Wojciech J.
More than a Genetic Code: Epigenetics of Lung Fibrosis
title More than a Genetic Code: Epigenetics of Lung Fibrosis
title_full More than a Genetic Code: Epigenetics of Lung Fibrosis
title_fullStr More than a Genetic Code: Epigenetics of Lung Fibrosis
title_full_unstemmed More than a Genetic Code: Epigenetics of Lung Fibrosis
title_short More than a Genetic Code: Epigenetics of Lung Fibrosis
title_sort more than a genetic code: epigenetics of lung fibrosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677145/
https://www.ncbi.nlm.nih.gov/pubmed/32926347
http://dx.doi.org/10.1007/s40291-020-00490-7
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