Cargando…

Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal

Skeletal muscle and bone are highly interrelated, and previous proteomic analyses suggest that lumican is one of muscle-derived factors. To further understand the role of lumican as a myokine affecting adjacent bone metabolism, we investigated the effects of lumican on osteoblast biology. Lumican ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jin Young, Park, So Jeong, Kim, Da Ae, Lee, Seung Hun, Koh, Jung-Min, Kim, Beom-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677261/ https://www.ncbi.nlm.nih.gov/pubmed/33240876 http://dx.doi.org/10.3389/fcell.2020.565826

Ejemplares similares

Lumican, an Exerkine, Protects against Skeletal Muscle Loss
por: Cho, Han Jin, et al.
Publicado: (2022)

Lumican Inhibits Osteoclastogenesis and Bone Resorption by Suppressing Akt Activity
por: Lee, Jin-Young, et al.
Publicado: (2021)

Label-Free Infrared Spectral Histology of Skin Tissue Part I: Impact of Lumican on Extracellular Matrix Integrity
por: Nannan, Lise, et al.
Publicado: (2020)

Label-Free Infrared Spectral Histology of Skin Tissue Part II: Impact of a Lumican-Derived Peptide on Melanoma Growth
por: Brézillon, Stéphane, et al.
Publicado: (2020)

Stimulator of Interferon Genes (STING) Promotes Staphylococcus aureus-Induced Extracellular Traps Formation via the ROS-ERK Signaling Pathway
por: Liu, Zhen-Zhen, et al.
Publicado: (2022)

Loss of α6β4 Integrin-Mediated Hemidesmosomes Promotes Prostate Epithelial Cell Migration by Stimulating Focal Adhesion Dynamics
por: Schmidt, Anette, et al.
Publicado: (2022)

FRET Visualization of Cyclic Stretch-Activated ERK via Calcium Channels Mechanosensation While Not Integrin β1 in Airway Smooth Muscle Cells
por: Fang, Xin, et al.
Publicado: (2022)

Benefits of lumican on human bone health: clinical evidence using bone marrow aspirates
por: Lee, Yun Sun, et al.
Publicado: (2022)

α-Enolase Lies Downstream of mTOR/HIF1α and Promotes Thyroid Carcinoma Progression by Regulating CST1
por: Liu, Yang, et al.
Publicado: (2021)

Ligand-bound integrin αvβ6 internalisation and trafficking
por: Meecham, Amelia, et al.
Publicado: (2022)

Lumican Accelerates Wound Healing by Enhancing α2β1 Integrin-Mediated Fibroblast Contractility
por: Liu, Xiao-Jin, et al.
Publicado: (2013)

Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation
por: Valat, Anne, et al.
Publicado: (2023)

α4/α9 Integrins Coordinate Epithelial Cell Migration Through Local Suppression of MAP Kinase Signaling Pathways
por: Hight-Warburton, Willow, et al.
Publicado: (2021)

Targeting Integrins for Cancer Therapy - Disappointments and Opportunities
por: Bergonzini, Cecilia, et al.
Publicado: (2022)

Role of Integrin αvβ3 in Doxycycline-Induced Anti-Proliferation in Breast Cancer Cells
por: Chen, Yi-Fong, et al.
Publicado: (2022)

O-GlcNAcylation Suppresses the Ion Current IClswell by Preventing the Binding of the Protein ICln to α-Integrin
por: Costa, Roberta, et al.
Publicado: (2020)

NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 Integrin
por: Alghamdi, Abdullah A. A., et al.
Publicado: (2020)

Extracellular Matrix Proteins Confer Cell Adhesion-Mediated Drug Resistance Through Integrin α(v) in Glioblastoma Cells
por: Yu, Qi, et al.
Publicado: (2021)

Membrane Binding of α-Synuclein Stimulates Expansion of SNARE-Dependent Fusion Pore
por: Khounlo, Ryan, et al.
Publicado: (2021)

Lumican in Carcinogenesis—Revisited
por: Giatagana, Eirini-Maria, et al.
Publicado: (2021)

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
por: Buscà, Roser, et al.
Publicado: (2016)

Dynamic Assembly of Human Salivary Stem/Progenitor Microstructures Requires Coordinated α(1)β(1) Integrin-Mediated Motility
por: Wu, Danielle, et al.
Publicado: (2019)

The Laminin Receptors Basal Cell Adhesion Molecule/Lutheran and Integrin α7β1 on Human Hematopoietic Stem Cells
por: Godavarthy, Parimala Sonika, et al.
Publicado: (2021)

Thy-1 in Integrin Mediated Mechanotransduction
por: Hu, Ping, et al.
Publicado: (2019)

Mechanistic Insight Into the Roles of Integrins in Osteoarthritis
por: Jin, Hongfu, et al.
Publicado: (2021)

CSK-mediated signalling by integrins in cancer
por: Maldonado, Horacio, et al.
Publicado: (2023)

Liprin-α-Mediated Assemblies and Their Roles in Synapse Formation
por: Xie, Xingqiao, et al.
Publicado: (2021)

Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells
por: Raina, Dhruv, et al.
Publicado: (2022)

Integrins and Epithelial-Mesenchymal Cooperation in the Tumor Microenvironment of Muscle-Invasive Lethal Cancers
por: Harryman, William L., et al.
Publicado: (2022)

The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin α5β1/ERK/Runx2 pathway
por: Oh, Sin-Hye, et al.
Publicado: (2017)

ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled?
por: Cook, Simon J., et al.
Publicado: (2022)

Editorial: Integrin adhesion receptors in health and disease
por: Kostourou, Vassiliki, et al.
Publicado: (2023)

Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican
por: Chakravarti, Shukti, et al.
Publicado: (1998)

The Role of Glial Mitochondria in α-Synuclein Toxicity
por: Jeon, Yu-Mi, et al.
Publicado: (2020)

Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1
por: Hipke, Katrin, et al.
Publicado: (2023)

A Novel Mutation in an NPXY Motif of β Integrin Reveals Phenotypes Similar to him-4/hemicentin
por: Qiu, Zhongqiang, et al.
Publicado: (2019)

Above the Matrix: Functional Roles for Apically Localized Integrins
por: Peterson, Raven J., et al.
Publicado: (2021)

Contribution of integrin adhesion to cytokinetic abscission and genomic integrity
por: Rani, Bhavna, et al.
Publicado: (2022)

The Role of Lumican in Ocular Disease
por: Amjadi, Shahriar, et al.
Publicado: (2013)

Mucin-Like Domain of Mucosal Addressin Cell Adhesion Molecule-1 Facilitates Integrin α4β7-Mediated Cell Adhesion Through Electrostatic Repulsion
por: Yuan, MengYa, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_afmsvcnalkifotb8tt6v0tgopq