Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration

Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-...

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Autores principales: Benissan-Messan, Dathe Z., Zhu, Hua, Zhong, Weina, Tan, Tao, Ma, Jianjie, Lee, Peter H. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677405/
https://www.ncbi.nlm.nih.gov/pubmed/33240103
http://dx.doi.org/10.3389/fphys.2020.583393
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author Benissan-Messan, Dathe Z.
Zhu, Hua
Zhong, Weina
Tan, Tao
Ma, Jianjie
Lee, Peter H. U.
author_facet Benissan-Messan, Dathe Z.
Zhu, Hua
Zhong, Weina
Tan, Tao
Ma, Jianjie
Lee, Peter H. U.
author_sort Benissan-Messan, Dathe Z.
collection PubMed
description Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein’s wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.
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spelling pubmed-76774052020-11-24 Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration Benissan-Messan, Dathe Z. Zhu, Hua Zhong, Weina Tan, Tao Ma, Jianjie Lee, Peter H. U. Front Physiol Physiology Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein’s wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed. Frontiers Media S.A. 2020-11-06 /pmc/articles/PMC7677405/ /pubmed/33240103 http://dx.doi.org/10.3389/fphys.2020.583393 Text en Copyright © 2020 Benissan-Messan, Zhu, Zhong, Tan, Ma and Lee. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Benissan-Messan, Dathe Z.
Zhu, Hua
Zhong, Weina
Tan, Tao
Ma, Jianjie
Lee, Peter H. U.
Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
title Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
title_full Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
title_fullStr Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
title_full_unstemmed Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
title_short Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration
title_sort multi-cellular functions of mg53 in muscle calcium signaling and regeneration
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677405/
https://www.ncbi.nlm.nih.gov/pubmed/33240103
http://dx.doi.org/10.3389/fphys.2020.583393
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