Lung-targeting lentiviral vector for passive immunisation against influenza

When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can d...

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Detalles Bibliográficos
Autores principales: Tan, Tiong Kit, Gamlen, Toby P E, Rijal, Pramila, Townsend, Alain R, Gill, Deborah R, Hyde, Stephen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677466/
https://www.ncbi.nlm.nih.gov/pubmed/32883885
http://dx.doi.org/10.1136/thoraxjnl-2020-214656
Descripción
Sumario:When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens.

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