Lung-targeting lentiviral vector for passive immunisation against influenza

When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can d...

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Autores principales: Tan, Tiong Kit, Gamlen, Toby P E, Rijal, Pramila, Townsend, Alain R, Gill, Deborah R, Hyde, Stephen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677466/
https://www.ncbi.nlm.nih.gov/pubmed/32883885
http://dx.doi.org/10.1136/thoraxjnl-2020-214656
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author Tan, Tiong Kit
Gamlen, Toby P E
Rijal, Pramila
Townsend, Alain R
Gill, Deborah R
Hyde, Stephen C
author_facet Tan, Tiong Kit
Gamlen, Toby P E
Rijal, Pramila
Townsend, Alain R
Gill, Deborah R
Hyde, Stephen C
author_sort Tan, Tiong Kit
collection PubMed
description When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens.
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spelling pubmed-76774662020-11-30 Lung-targeting lentiviral vector for passive immunisation against influenza Tan, Tiong Kit Gamlen, Toby P E Rijal, Pramila Townsend, Alain R Gill, Deborah R Hyde, Stephen C Thorax Brief Communication When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens. BMJ Publishing Group 2020-12 2020-09-03 /pmc/articles/PMC7677466/ /pubmed/32883885 http://dx.doi.org/10.1136/thoraxjnl-2020-214656 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Tan, Tiong Kit
Gamlen, Toby P E
Rijal, Pramila
Townsend, Alain R
Gill, Deborah R
Hyde, Stephen C
Lung-targeting lentiviral vector for passive immunisation against influenza
title Lung-targeting lentiviral vector for passive immunisation against influenza
title_full Lung-targeting lentiviral vector for passive immunisation against influenza
title_fullStr Lung-targeting lentiviral vector for passive immunisation against influenza
title_full_unstemmed Lung-targeting lentiviral vector for passive immunisation against influenza
title_short Lung-targeting lentiviral vector for passive immunisation against influenza
title_sort lung-targeting lentiviral vector for passive immunisation against influenza
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677466/
https://www.ncbi.nlm.nih.gov/pubmed/32883885
http://dx.doi.org/10.1136/thoraxjnl-2020-214656
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