Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort

PARP inhibitors have shown remarkable efficacy in the clinical management of several BRCA-mutated tumors. This approach is based on the long-standing hypothesis that PARP inhibition will impair the repair of single stranded breaks, causing synthetic lethality in tumors with loss of high-fidelity dou...

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Detalles Bibliográficos
Autores principales: Principe, Daniel R., Narbutis, Matthew, Koch, Regina, Rana, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677533/
https://www.ncbi.nlm.nih.gov/pubmed/33214570
http://dx.doi.org/10.1038/s41598-020-76975-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677533/
https://www.ncbi.nlm.nih.gov/pubmed/33214570
http://dx.doi.org/10.1038/s41598-020-76975-6

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