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Frequency and prognostic value of mutations associated with the homologous recombination DNA repair pathway in a large pan cancer cohort
PARP inhibitors have shown remarkable efficacy in the clinical management of several BRCA-mutated tumors. This approach is based on the long-standing hypothesis that PARP inhibition will impair the repair of single stranded breaks, causing synthetic lethality in tumors with loss of high-fidelity dou...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677533/ https://www.ncbi.nlm.nih.gov/pubmed/33214570 http://dx.doi.org/10.1038/s41598-020-76975-6 |