Cardiac lesions in Duchenne muscular dystrophy model rats with out-of-frame Dmd gene mutation mediated by CRISPR/Cas9 system

Duchenne muscular dystrophy (DMD) is a progressive muscular disorder caused by X-chromosomal DMD gene mutations. Recently, a new CRISPR/Cas9-mediated DMD rat model (cDMDR) was established and is expected to show cardiac lesions similar to those in humans. We therefore investigated the pathological a...

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Detalles Bibliográficos
Autores principales: Miyamoto, Mao, Tochinai, Ryota, Sekizawa, Shin-ich, Shiga, Takanori, Uchida, Kazuyuki, Tsuru, Yoshiharu, Kuwahara, Masayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677620/
https://www.ncbi.nlm.nih.gov/pubmed/33239841
http://dx.doi.org/10.1293/tox.2020-0018

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