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Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross

BACKGROUND: Lumefantrine and mefloquine are used worldwide in artemisinin-based combination therapy (ACT) of malaria. Better understanding of drug susceptibility and resistance is needed and can be obtained from studies of genetic crosses. METHODS: Drug response phenotypes of a cross between Plasmod...

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Detalles Bibliográficos
Autores principales: Windle, Sean T., Lane, Kristin D., Gadalla, Nahla B., Liu, Anna, Mu, Jianbing, Caleon, Ramoncito L., Rahman, Rifat S., Sá, Juliana M., Wellems, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677662/
https://www.ncbi.nlm.nih.gov/pubmed/33197753
http://dx.doi.org/10.1016/j.ijpddr.2020.10.009