Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

The nucleocapsid (N) protein of coronaviruses serves two major functions: compaction of the RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N protein mediates such distinct functions. The N protein contains two RNA-binding domains surrounded by regions of...

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Detalles Bibliográficos
Autores principales: Carlson, Christopher R., Asfaha, Jonathan B., Ghent, Chloe M., Howard, Conor J., Hartooni, Nairi, Safari, Maliheh, Frankel, Alan D., Morgan, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677695/
https://www.ncbi.nlm.nih.gov/pubmed/33248025
http://dx.doi.org/10.1016/j.molcel.2020.11.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677695/
https://www.ncbi.nlm.nih.gov/pubmed/33248025
http://dx.doi.org/10.1016/j.molcel.2020.11.025

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