Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy

Chronic alcoholism disrupts mitochondrial function and often results in alcoholic cardiomyopathy (ACM). Fas-activated serine/threonine kinase (FASTK) is newly recognized as a key post-transcriptional regulator of mitochondrial gene expression. However, the modulatory role of FASTK in cardiovascular...

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Detalles Bibliográficos
Autores principales: Zhang, Fuyang, Wang, Kai, Zhang, Shumiao, Li, Juan, Fan, Rong, Chen, Xiyao, Pei, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677712/
https://www.ncbi.nlm.nih.gov/pubmed/33197770
http://dx.doi.org/10.1016/j.redox.2020.101778

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