Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice

BACKGROUND: The R1441G mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results in late-onset Parkinson’s disease (PD). Peripheral inflammation and gut microbiota are closely associated with the pathogenesis of PD. Chronic periodontitis is a common type of peripheral inflammation, which is...

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Detalles Bibliográficos
Autores principales: Feng, Yu-Kun, Wu, Qiong-Li, Peng, Yan-Wen, Liang, Feng-Yin, You, Hua-Jing, Feng, Yi-Wei, Li, Ge, Li, Xue-Jiao, Liu, Shu-Hua, Li, Yong-Chao, Zhang, Yu, Pei, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677837/
https://www.ncbi.nlm.nih.gov/pubmed/33213462
http://dx.doi.org/10.1186/s12974-020-02027-5

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