LRRK2 and the Endolysosomal System in Parkinson’s Disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial Parkinson’s disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity. There is a growing body of evidence indicating that LRRK2 contributes to neuronal damage and pathology both in familial and sporadi...

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Detalles Bibliográficos
Autores principales: Erb, Madalynn L., Moore, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677880/
https://www.ncbi.nlm.nih.gov/pubmed/33044192
http://dx.doi.org/10.3233/JPD-202138

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