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Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters

BACKGROUND: To assess the corneal stress-strain index (SSI), which is a marker for material stiffness and corneal biomechanical parameters, in myopic eyes. METHODS: A total of 1054 myopic patients were included in this study. Corneal visualisation Scheimpflug technology was used to measure the SSI....

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Autores principales: Han, Fang, Li, Mengdi, Wei, Pinghui, Ma, Jiaonan, Jhanji, Vishal, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678063/
https://www.ncbi.nlm.nih.gov/pubmed/33213408
http://dx.doi.org/10.1186/s12886-020-01729-x
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author Han, Fang
Li, Mengdi
Wei, Pinghui
Ma, Jiaonan
Jhanji, Vishal
Wang, Yan
author_facet Han, Fang
Li, Mengdi
Wei, Pinghui
Ma, Jiaonan
Jhanji, Vishal
Wang, Yan
author_sort Han, Fang
collection PubMed
description BACKGROUND: To assess the corneal stress-strain index (SSI), which is a marker for material stiffness and corneal biomechanical parameters, in myopic eyes. METHODS: A total of 1054 myopic patients were included in this study. Corneal visualisation Scheimpflug technology was used to measure the SSI. Corneal biomechanics were assessed using the first and second applanation times (A1-and A2-times); maximum deflection amplitude (DefAmax); deflection area (HCDefArea); the highest concavity peak distance (HC-PD), time (HC-time), and deflection amplitude (HC-DefA); integrated radius (IR); whole eye movement (WEM); stiffness parameter (SP-A1;, biomechanically corrected intraocular pressure (BIOP); and Corvis biomechanical index (CBI). Scheimpflug tomography was used to obtain the mean keratometery (Km) and central corneal thickness (CCT). According to the spherical equivalent (SE) (low myopia: SE ≥ − 3.00D and high myopia: SE ≤ − 6.00D.), the suitable patients were divided into two groups. RESULTS: The mean SSI value was 0.854 ± 0.004. The SSI had a positive correlation with A1-time ((r = 0.272), HC-time (r = 0.218), WEM (r = 0.288), SP-A1 (r = 0.316), CBI (r = 0.199), CCT (r = 0.125), bIOP (r = 0.230), and SE (r = 0.313) (all p-values<0.01). The SSI had a negative correlation with HCDefA (r = − 0.721), HCDefArea (r = − 0.665), HC-PD(r = − 0.597), IR (r = − 0.555), DefAmax (r = − 0.564), and Km (r = − 0.103) (all p-values<0.01). There were significant differences in SSI (t = 8.960, p<0.01) and IR (t = − 3.509, p<0.01) between the low and high myopia groups. CONCLUSIONS: In different grades of myopia, the SSI values were lower in eyes with higher SEs. It indicates that the mechanical strength of the cornea may be compromised in high myopia. The SSI was positively correlated with the spherical equivalent, and it may provide a new way to study the mechanism of myopia.
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spelling pubmed-76780632020-11-20 Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters Han, Fang Li, Mengdi Wei, Pinghui Ma, Jiaonan Jhanji, Vishal Wang, Yan BMC Ophthalmol Research Article BACKGROUND: To assess the corneal stress-strain index (SSI), which is a marker for material stiffness and corneal biomechanical parameters, in myopic eyes. METHODS: A total of 1054 myopic patients were included in this study. Corneal visualisation Scheimpflug technology was used to measure the SSI. Corneal biomechanics were assessed using the first and second applanation times (A1-and A2-times); maximum deflection amplitude (DefAmax); deflection area (HCDefArea); the highest concavity peak distance (HC-PD), time (HC-time), and deflection amplitude (HC-DefA); integrated radius (IR); whole eye movement (WEM); stiffness parameter (SP-A1;, biomechanically corrected intraocular pressure (BIOP); and Corvis biomechanical index (CBI). Scheimpflug tomography was used to obtain the mean keratometery (Km) and central corneal thickness (CCT). According to the spherical equivalent (SE) (low myopia: SE ≥ − 3.00D and high myopia: SE ≤ − 6.00D.), the suitable patients were divided into two groups. RESULTS: The mean SSI value was 0.854 ± 0.004. The SSI had a positive correlation with A1-time ((r = 0.272), HC-time (r = 0.218), WEM (r = 0.288), SP-A1 (r = 0.316), CBI (r = 0.199), CCT (r = 0.125), bIOP (r = 0.230), and SE (r = 0.313) (all p-values<0.01). The SSI had a negative correlation with HCDefA (r = − 0.721), HCDefArea (r = − 0.665), HC-PD(r = − 0.597), IR (r = − 0.555), DefAmax (r = − 0.564), and Km (r = − 0.103) (all p-values<0.01). There were significant differences in SSI (t = 8.960, p<0.01) and IR (t = − 3.509, p<0.01) between the low and high myopia groups. CONCLUSIONS: In different grades of myopia, the SSI values were lower in eyes with higher SEs. It indicates that the mechanical strength of the cornea may be compromised in high myopia. The SSI was positively correlated with the spherical equivalent, and it may provide a new way to study the mechanism of myopia. BioMed Central 2020-11-19 /pmc/articles/PMC7678063/ /pubmed/33213408 http://dx.doi.org/10.1186/s12886-020-01729-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Han, Fang
Li, Mengdi
Wei, Pinghui
Ma, Jiaonan
Jhanji, Vishal
Wang, Yan
Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
title Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
title_full Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
title_fullStr Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
title_full_unstemmed Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
title_short Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
title_sort effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678063/
https://www.ncbi.nlm.nih.gov/pubmed/33213408
http://dx.doi.org/10.1186/s12886-020-01729-x
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