Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size

BACKGROUND: Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibitors emerged in the therapy of diverse cancers. In colorectal cancer, the commo...

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Detalles Bibliográficos
Autores principales: Ben Jemii, Nadia, Tounsi-Kettiti, Haifa, Yaiche, Hamza, Mezghanni, Najla, Jaballah Gabteni, Amira, Fehri, Emna, Ben Fayala, Chayma, Abdelhak, Sonia, Boubaker, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678118/
https://www.ncbi.nlm.nih.gov/pubmed/33213472
http://dx.doi.org/10.1186/s12967-020-02614-3

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