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High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats

BACKGROUND: Paternal obesity has been associated with reduced live birth rates. It could lead to inheritance of metabolic disturbances to the offspring through epigenetic mechanisms. However, obesity is a multifactorial disorder with genetic or environmental causes. Earlier we had demonstrated diffe...

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Detalles Bibliográficos
Autores principales: Deshpande, Sharvari S., Nemani, Harishankar, Arumugam, Gandhimathi, Ravichandran, Avinash, Balasinor, Nafisa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678167/
https://www.ncbi.nlm.nih.gov/pubmed/33213487
http://dx.doi.org/10.1186/s13148-020-00974-7