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Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast
BACKGROUND: High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678216/ https://www.ncbi.nlm.nih.gov/pubmed/33218360 http://dx.doi.org/10.1186/s13000-020-01050-7 |
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author | Oramas, Diana M. Bell, Diana Middleton, Lavinia P. |
author_facet | Oramas, Diana M. Bell, Diana Middleton, Lavinia P. |
author_sort | Oramas, Diana M. |
collection | PubMed |
description | BACKGROUND: High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defining feature of association with high risk HPV. CASE PRESENTATION: We present a case of a perimenopausal woman with a non-healing ulcerated lesion involving the nipple and breast following a trauma. Biopsy performed showed an HPV-positive basal-like carcinoma with squamous differentiation involving the breast, analogous to multiphenotypic carcinoma previously described in the sinonasal tract. CONCLUSION: This is the first report of a case of a high- risk HPV related basal-like carcinoma with squamous differentiation, described in the literature. We highlight the morphology and immunophenotype of this lesion and its recognition when compared to other multiphenotypic lesions of the breast, and suggest that pathologists should consider HPV evaluation when encountering similar basal-like tumors involving the breast. |
format | Online Article Text |
id | pubmed-7678216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76782162020-11-20 Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast Oramas, Diana M. Bell, Diana Middleton, Lavinia P. Diagn Pathol Case Report BACKGROUND: High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma has overlapping histology with basal-like breast carcinomas, but carry the defining feature of association with high risk HPV. CASE PRESENTATION: We present a case of a perimenopausal woman with a non-healing ulcerated lesion involving the nipple and breast following a trauma. Biopsy performed showed an HPV-positive basal-like carcinoma with squamous differentiation involving the breast, analogous to multiphenotypic carcinoma previously described in the sinonasal tract. CONCLUSION: This is the first report of a case of a high- risk HPV related basal-like carcinoma with squamous differentiation, described in the literature. We highlight the morphology and immunophenotype of this lesion and its recognition when compared to other multiphenotypic lesions of the breast, and suggest that pathologists should consider HPV evaluation when encountering similar basal-like tumors involving the breast. BioMed Central 2020-11-20 /pmc/articles/PMC7678216/ /pubmed/33218360 http://dx.doi.org/10.1186/s13000-020-01050-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Oramas, Diana M. Bell, Diana Middleton, Lavinia P. Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |
title | Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |
title_full | Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |
title_fullStr | Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |
title_full_unstemmed | Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |
title_short | Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |
title_sort | sinonasal analogue hpv related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678216/ https://www.ncbi.nlm.nih.gov/pubmed/33218360 http://dx.doi.org/10.1186/s13000-020-01050-7 |
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