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Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates
INTRODUCTION: Racial differences in the association between type 1 diabetes mellitus (T1DM) and large-for-gestational-age (LGA) neonates remain unclear. The objective of this study was to compare the effect of T1DM on LGA neonates between Caucasian and Asian women. RESEARCH DESIGN AND METHODS: A pop...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678233/ https://www.ncbi.nlm.nih.gov/pubmed/33214189 http://dx.doi.org/10.1136/bmjdrc-2020-001746 |
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author | Guo, Yanfang Luo, Rong Corsi, Daniel J Retnakaran, Ravi Walker, Mark C Wen, Shi Wu |
author_facet | Guo, Yanfang Luo, Rong Corsi, Daniel J Retnakaran, Ravi Walker, Mark C Wen, Shi Wu |
author_sort | Guo, Yanfang |
collection | PubMed |
description | INTRODUCTION: Racial differences in the association between type 1 diabetes mellitus (T1DM) and large-for-gestational-age (LGA) neonates remain unclear. The objective of this study was to compare the effect of T1DM on LGA neonates between Caucasian and Asian women. RESEARCH DESIGN AND METHODS: A population-based retrospective cohort study was conducted among Caucasian and Asian women who had prenatal screening and gave a singleton live birth in an Ontario hospital between April 2015 and March 2018. Multivariable log-binomial regression models were used to estimate the adjusted relative risks (aRRs) and 95% CIs of T1DM on LGA for Caucasian and Asian women. Relative contribution of T1DM to LGA was examined by multivariable logistic regression model, stratified by Caucasian and Asian women. RESULTS: A total of 232 503 women (69.4% Caucasians and 30.6% Asians) were included in the final analysis. The rate of T1DM was higher in Caucasians (0.5%) than in Asians (0.2%), and the rate of LGA neonates was also higher in Caucasians (11.0%) than in Asians (5.0%). The association between T1DM and LGA in Caucasians (aRR 4.18, 95% CI (3.84 to 4.55)) was more robust than that in Asians (aRR 2.11, 95% CI (1.24 to 3.59)). T1DM was the fourth strongest contributor to LGA in Caucasians, while T1DM was the seventh contributor to LGA in Asians. CONCLUSIONS: T1DM plays a more substantial role in LGA among Caucasians than Asians. Clinicians should be aware of the Caucasian–Asian differences of effects of T1DM on LGA when developing pregnancy management strategies. |
format | Online Article Text |
id | pubmed-7678233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-76782332020-11-30 Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates Guo, Yanfang Luo, Rong Corsi, Daniel J Retnakaran, Ravi Walker, Mark C Wen, Shi Wu BMJ Open Diabetes Res Care Epidemiology/Health services research INTRODUCTION: Racial differences in the association between type 1 diabetes mellitus (T1DM) and large-for-gestational-age (LGA) neonates remain unclear. The objective of this study was to compare the effect of T1DM on LGA neonates between Caucasian and Asian women. RESEARCH DESIGN AND METHODS: A population-based retrospective cohort study was conducted among Caucasian and Asian women who had prenatal screening and gave a singleton live birth in an Ontario hospital between April 2015 and March 2018. Multivariable log-binomial regression models were used to estimate the adjusted relative risks (aRRs) and 95% CIs of T1DM on LGA for Caucasian and Asian women. Relative contribution of T1DM to LGA was examined by multivariable logistic regression model, stratified by Caucasian and Asian women. RESULTS: A total of 232 503 women (69.4% Caucasians and 30.6% Asians) were included in the final analysis. The rate of T1DM was higher in Caucasians (0.5%) than in Asians (0.2%), and the rate of LGA neonates was also higher in Caucasians (11.0%) than in Asians (5.0%). The association between T1DM and LGA in Caucasians (aRR 4.18, 95% CI (3.84 to 4.55)) was more robust than that in Asians (aRR 2.11, 95% CI (1.24 to 3.59)). T1DM was the fourth strongest contributor to LGA in Caucasians, while T1DM was the seventh contributor to LGA in Asians. CONCLUSIONS: T1DM plays a more substantial role in LGA among Caucasians than Asians. Clinicians should be aware of the Caucasian–Asian differences of effects of T1DM on LGA when developing pregnancy management strategies. BMJ Publishing Group 2020-11-19 /pmc/articles/PMC7678233/ /pubmed/33214189 http://dx.doi.org/10.1136/bmjdrc-2020-001746 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Epidemiology/Health services research Guo, Yanfang Luo, Rong Corsi, Daniel J Retnakaran, Ravi Walker, Mark C Wen, Shi Wu Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates |
title | Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates |
title_full | Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates |
title_fullStr | Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates |
title_full_unstemmed | Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates |
title_short | Caucasian and Asian difference in role of type 1 diabetes on large-for-gestational-age neonates |
title_sort | caucasian and asian difference in role of type 1 diabetes on large-for-gestational-age neonates |
topic | Epidemiology/Health services research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678233/ https://www.ncbi.nlm.nih.gov/pubmed/33214189 http://dx.doi.org/10.1136/bmjdrc-2020-001746 |
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