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A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer
Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to play a major role in such resistance, but N-terminal inhibitors of this target have had little success. We sought to investigate the utility of NCT-547, a novel, rationally-designed C-ter...
Autores principales: | Park, Jung Min, Kim, Yoon-Jae, Park, Soeun, Park, Minsu, Farrand, Lee, Nguyen, Cong-Truong, Ann, Jihyae, Nam, Gibeom, Park, Hyun-Ju, Lee, Jeewoo, Kim, Ji Young, Seo, Jae Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678296/ https://www.ncbi.nlm.nih.gov/pubmed/33218356 http://dx.doi.org/10.1186/s12943-020-01283-6 |
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