Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses

Colchicine is an anti-inflammatory agent which has been used for decades in the treatment of gout. The drug has a number of dermatological indications like Psoriasis, Sweet's syndrome, aphthosis, Behcet's disease, erythema nodosum, leukocytoclastic vasculitis and is consistently effective...

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Detalles Bibliográficos
Autores principales: Sardana, Kabir, Sinha, Surabhi, Sachdeva, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678539/
https://www.ncbi.nlm.nih.gov/pubmed/33235833
http://dx.doi.org/10.4103/idoj.IDOJ_475_20
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author Sardana, Kabir
Sinha, Surabhi
Sachdeva, Soumya
author_facet Sardana, Kabir
Sinha, Surabhi
Sachdeva, Soumya
author_sort Sardana, Kabir
collection PubMed
description Colchicine is an anti-inflammatory agent which has been used for decades in the treatment of gout. The drug has a number of dermatological indications like Psoriasis, Sweet's syndrome, aphthosis, Behcet's disease, erythema nodosum, leukocytoclastic vasculitis and is consistently effective in neutrophilic disorders. Thought it is an affordable with minimal side effects, It has remained underutilized. However, it has novel uses and is being considered in COVID-19 due to its action on IL-1β and IL-6. This article presents a concise and up-to-date review focusing on its mechanisms of action and indications.
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spelling pubmed-76785392020-11-23 Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses Sardana, Kabir Sinha, Surabhi Sachdeva, Soumya Indian Dermatol Online J Review Article Colchicine is an anti-inflammatory agent which has been used for decades in the treatment of gout. The drug has a number of dermatological indications like Psoriasis, Sweet's syndrome, aphthosis, Behcet's disease, erythema nodosum, leukocytoclastic vasculitis and is consistently effective in neutrophilic disorders. Thought it is an affordable with minimal side effects, It has remained underutilized. However, it has novel uses and is being considered in COVID-19 due to its action on IL-1β and IL-6. This article presents a concise and up-to-date review focusing on its mechanisms of action and indications. Wolters Kluwer - Medknow 2020-09-19 /pmc/articles/PMC7678539/ /pubmed/33235833 http://dx.doi.org/10.4103/idoj.IDOJ_475_20 Text en Copyright: © 2020 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Sardana, Kabir
Sinha, Surabhi
Sachdeva, Soumya
Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses
title Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses
title_full Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses
title_fullStr Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses
title_full_unstemmed Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses
title_short Colchicine in Dermatology: Rediscovering an Old Drug with Novel Uses
title_sort colchicine in dermatology: rediscovering an old drug with novel uses
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678539/
https://www.ncbi.nlm.nih.gov/pubmed/33235833
http://dx.doi.org/10.4103/idoj.IDOJ_475_20
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