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Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population

Background: Cumulative evidence suggests that both traumatic stress and posttraumatic stress disorder (PTSD) are cross-sectionally and prospectively linked to cardiovascular disease (CVD). However, their association with proxy markers of atherosclerosis has hardly been investigated. Objective: The o...

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Autores principales: Spitzer, Carsten, Klinger-König, Johanna, Frenzel, Stefan, Schminke, Ulf, Völzke, Henry, Lübke, Laura, Grabe, Hans Jörgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678678/
https://www.ncbi.nlm.nih.gov/pubmed/33244360
http://dx.doi.org/10.1080/20008198.2020.1815280
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author Spitzer, Carsten
Klinger-König, Johanna
Frenzel, Stefan
Schminke, Ulf
Völzke, Henry
Lübke, Laura
Grabe, Hans Jörgen
author_facet Spitzer, Carsten
Klinger-König, Johanna
Frenzel, Stefan
Schminke, Ulf
Völzke, Henry
Lübke, Laura
Grabe, Hans Jörgen
author_sort Spitzer, Carsten
collection PubMed
description Background: Cumulative evidence suggests that both traumatic stress and posttraumatic stress disorder (PTSD) are cross-sectionally and prospectively linked to cardiovascular disease (CVD). However, their association with proxy markers of atherosclerosis has hardly been investigated. Objective: The objective of this general population study was to relate traumatic stress and PTSD to carotid plaque and intima-media thickness (cIMT). Methods: 3119 adults from the general population were assessed regarding their traditional cardiovascular risk factors, and an ultrasound of the carotid arteries was performed in each participant. Based on a PTSD interview, every participant was assigned to one of three groups: no trauma; trauma, but no PTSD; and trauma with PTSD. The sample was stratified into five age groups. Results: Trauma exposure was reported by 54.5% of the sample and 2.0% had PTSD. Traumatized participants had increased odds of self-reported CVD events compared to those without trauma exposure, even when accounted for CVD risk factors and other covariates (odds ratio [OR] = 1.51; 95% confidence interval [CI]: 1.03–2.22). This association was driven by those aged 70 years or older. Only in those aged 40 to 49 years, there was an association between cIMT and PTSD. There were no further associations between carotid plaque or cIMT and traumatic stress or PTSD. Conclusions: Our findings in concert with prior research suggest that the association between traumatic stress, PTSD and atherosclerosis as well as its clinical endpoints is complex and remains inconclusive.
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spelling pubmed-76786782020-11-25 Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population Spitzer, Carsten Klinger-König, Johanna Frenzel, Stefan Schminke, Ulf Völzke, Henry Lübke, Laura Grabe, Hans Jörgen Eur J Psychotraumatol Clinical Research Article Background: Cumulative evidence suggests that both traumatic stress and posttraumatic stress disorder (PTSD) are cross-sectionally and prospectively linked to cardiovascular disease (CVD). However, their association with proxy markers of atherosclerosis has hardly been investigated. Objective: The objective of this general population study was to relate traumatic stress and PTSD to carotid plaque and intima-media thickness (cIMT). Methods: 3119 adults from the general population were assessed regarding their traditional cardiovascular risk factors, and an ultrasound of the carotid arteries was performed in each participant. Based on a PTSD interview, every participant was assigned to one of three groups: no trauma; trauma, but no PTSD; and trauma with PTSD. The sample was stratified into five age groups. Results: Trauma exposure was reported by 54.5% of the sample and 2.0% had PTSD. Traumatized participants had increased odds of self-reported CVD events compared to those without trauma exposure, even when accounted for CVD risk factors and other covariates (odds ratio [OR] = 1.51; 95% confidence interval [CI]: 1.03–2.22). This association was driven by those aged 70 years or older. Only in those aged 40 to 49 years, there was an association between cIMT and PTSD. There were no further associations between carotid plaque or cIMT and traumatic stress or PTSD. Conclusions: Our findings in concert with prior research suggest that the association between traumatic stress, PTSD and atherosclerosis as well as its clinical endpoints is complex and remains inconclusive. Taylor & Francis 2020-10-14 /pmc/articles/PMC7678678/ /pubmed/33244360 http://dx.doi.org/10.1080/20008198.2020.1815280 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Spitzer, Carsten
Klinger-König, Johanna
Frenzel, Stefan
Schminke, Ulf
Völzke, Henry
Lübke, Laura
Grabe, Hans Jörgen
Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population
title Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population
title_full Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population
title_fullStr Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population
title_full_unstemmed Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population
title_short Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population
title_sort association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678678/
https://www.ncbi.nlm.nih.gov/pubmed/33244360
http://dx.doi.org/10.1080/20008198.2020.1815280
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