Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI

Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers available to detect DOX-cardiotoxicity before functional decline. Mitochondrial dys...

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Detalles Bibliográficos
Autores principales: Timm, Kerstin N., Perera, Charith, Ball, Vicky, Henry, John A., Miller, Jack J., Kerr, Matthew, West, James A., Sharma, Eshita, Broxholme, John, Logan, Angela, Savic, Dragana, Dodd, Michael S., Griffin, Julian L., Murphy, Michael P., Heather, Lisa C., Tyler, Damian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678845/
https://www.ncbi.nlm.nih.gov/pubmed/33214680
http://dx.doi.org/10.1038/s42003-020-01440-z

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