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Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia
The aim of the study was to retrospectively compare the effectiveness of the ALL IC-BFM 2002 and ALL IC-BFM 2009 protocols and the distribution of risk groups by the two protocols after minimal residual disease (MRD) measurement as well as its impact on survival. We reviewed the medical records of 3...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678856/ https://www.ncbi.nlm.nih.gov/pubmed/33214594 http://dx.doi.org/10.1038/s41598-020-75860-6 |
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| author | Zawitkowska, Joanna Lejman, Monika Romiszewski, Michał Matysiak, Michał Ćwiklińska, Magdalena Balwierz, Walentyna Owoc-Lempach, Joanna Kazanowska, Bernarda Derwich, Katarzyna Wachowiak, Jacek Niedźwiecki, Maciej Adamkiewicz-Drożyńska, Elżbieta Trelińska, Joanna Młynarski, Wojciech Kołtan, Andrzej Wysocki, Mariusz Tomaszewska, Renata Szczepański, Tomasz Płonowski, Marcin Krawczuk-Rybak, Maryna Urbańska-Rakus, Justyna Machnik, Katarzyna Ociepa, Tomasz Urasiński, Tomasz Mizia-Malarz, Agnieszka Sobol-Milejska, Grażyna Karolczyk, Grażyna Kowalczyk, Jerzy |
| author_facet | Zawitkowska, Joanna Lejman, Monika Romiszewski, Michał Matysiak, Michał Ćwiklińska, Magdalena Balwierz, Walentyna Owoc-Lempach, Joanna Kazanowska, Bernarda Derwich, Katarzyna Wachowiak, Jacek Niedźwiecki, Maciej Adamkiewicz-Drożyńska, Elżbieta Trelińska, Joanna Młynarski, Wojciech Kołtan, Andrzej Wysocki, Mariusz Tomaszewska, Renata Szczepański, Tomasz Płonowski, Marcin Krawczuk-Rybak, Maryna Urbańska-Rakus, Justyna Machnik, Katarzyna Ociepa, Tomasz Urasiński, Tomasz Mizia-Malarz, Agnieszka Sobol-Milejska, Grażyna Karolczyk, Grażyna Kowalczyk, Jerzy |
| author_sort | Zawitkowska, Joanna |
| collection | PubMed |
| description | The aim of the study was to retrospectively compare the effectiveness of the ALL IC-BFM 2002 and ALL IC-BFM 2009 protocols and the distribution of risk groups by the two protocols after minimal residual disease (MRD) measurement as well as its impact on survival. We reviewed the medical records of 3248 patients aged 1–18 years with newly diagnosed ALL who were treated in 14 hemato-oncological centers between 2002 and 2018 in Poland. The overall survival (OS) of 1872 children with ALL treated with the ALL IC 2002 protocol was 84% after 3 years, whereas the OS of 1376 children with ALL treated with the ALL IC 2009 protocol was 87% (P < 0.001). The corresponding event-free survival rates were 82% and 84% (P = 0.006). Our study shows that the ALL IC-BFM 2009 protocol improved the results of children with ALL compared to the ALL IC-BFM 2002 protocol in Poland. This analysis confirms that MRD marrow assessment on day 15 of treatment by FCM-MRD is an important predictive factor. |
| format | Online Article Text |
| id | pubmed-7678856 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76788562020-11-23 Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia Zawitkowska, Joanna Lejman, Monika Romiszewski, Michał Matysiak, Michał Ćwiklińska, Magdalena Balwierz, Walentyna Owoc-Lempach, Joanna Kazanowska, Bernarda Derwich, Katarzyna Wachowiak, Jacek Niedźwiecki, Maciej Adamkiewicz-Drożyńska, Elżbieta Trelińska, Joanna Młynarski, Wojciech Kołtan, Andrzej Wysocki, Mariusz Tomaszewska, Renata Szczepański, Tomasz Płonowski, Marcin Krawczuk-Rybak, Maryna Urbańska-Rakus, Justyna Machnik, Katarzyna Ociepa, Tomasz Urasiński, Tomasz Mizia-Malarz, Agnieszka Sobol-Milejska, Grażyna Karolczyk, Grażyna Kowalczyk, Jerzy Sci Rep Article The aim of the study was to retrospectively compare the effectiveness of the ALL IC-BFM 2002 and ALL IC-BFM 2009 protocols and the distribution of risk groups by the two protocols after minimal residual disease (MRD) measurement as well as its impact on survival. We reviewed the medical records of 3248 patients aged 1–18 years with newly diagnosed ALL who were treated in 14 hemato-oncological centers between 2002 and 2018 in Poland. The overall survival (OS) of 1872 children with ALL treated with the ALL IC 2002 protocol was 84% after 3 years, whereas the OS of 1376 children with ALL treated with the ALL IC 2009 protocol was 87% (P < 0.001). The corresponding event-free survival rates were 82% and 84% (P = 0.006). Our study shows that the ALL IC-BFM 2009 protocol improved the results of children with ALL compared to the ALL IC-BFM 2002 protocol in Poland. This analysis confirms that MRD marrow assessment on day 15 of treatment by FCM-MRD is an important predictive factor. Nature Publishing Group UK 2020-11-19 /pmc/articles/PMC7678856/ /pubmed/33214594 http://dx.doi.org/10.1038/s41598-020-75860-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Zawitkowska, Joanna Lejman, Monika Romiszewski, Michał Matysiak, Michał Ćwiklińska, Magdalena Balwierz, Walentyna Owoc-Lempach, Joanna Kazanowska, Bernarda Derwich, Katarzyna Wachowiak, Jacek Niedźwiecki, Maciej Adamkiewicz-Drożyńska, Elżbieta Trelińska, Joanna Młynarski, Wojciech Kołtan, Andrzej Wysocki, Mariusz Tomaszewska, Renata Szczepański, Tomasz Płonowski, Marcin Krawczuk-Rybak, Maryna Urbańska-Rakus, Justyna Machnik, Katarzyna Ociepa, Tomasz Urasiński, Tomasz Mizia-Malarz, Agnieszka Sobol-Milejska, Grażyna Karolczyk, Grażyna Kowalczyk, Jerzy Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia |
| title | Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia |
| title_full | Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia |
| title_fullStr | Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia |
| title_full_unstemmed | Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia |
| title_short | Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia |
| title_sort | results of two consecutive treatment protocols in polish children with acute lymphoblastic leukemia |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678856/ https://www.ncbi.nlm.nih.gov/pubmed/33214594 http://dx.doi.org/10.1038/s41598-020-75860-6 |
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