Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

Prenatal smoke exposure (PSE) is a risk factor for nicotine dependence. One susceptibility gene for nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine and nicotine clearance in the liver. Higher activity of the CYP2A6 enzyme is associat...

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Detalles Bibliográficos
Autores principales: Lkhagvadorj, Khosbayar, Meyer, Karolin F., Verweij, Laura P., Kooistra, Wierd, Reinders-Luinge, Marjan, Dijkhuizen, Henk W., de Graaf, Inge A. M., Plösch, Torsten, Hylkema, Machteld N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678918/
https://www.ncbi.nlm.nih.gov/pubmed/32573327
http://dx.doi.org/10.1080/15592294.2020.1782655

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