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Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil

The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the state of Rio Grande do Norte, and the aims were to describe the epidemiologic...

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Autores principales: Monteiro, Joelma D., Valverde, Joanna Gardel, Morais, Ingryd Camara, Souza, Cassio Ricardo de Medeiros, Fagundes Neto, João Ciro, de Melo, Marília Farias, Nascimento, Yasmin Mesquita, Alves, Brenda Elen Bizerra, de Medeiros, Leandro Gurgel, Pereira, Hannaly W. Bezerra, de Paiva, Anne Aline Pereira, Teixeira, Diego G., Moura, Márcia Cristina Bernardo de Melo, Tavares, Alessandre de Medeiros, Fernandes, José Veríssimo, Jeronimo, Selma M. B., Araújo, Josélio M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678967/
https://www.ncbi.nlm.nih.gov/pubmed/33216743
http://dx.doi.org/10.1371/journal.pone.0241799
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author Monteiro, Joelma D.
Valverde, Joanna Gardel
Morais, Ingryd Camara
Souza, Cassio Ricardo de Medeiros
Fagundes Neto, João Ciro
de Melo, Marília Farias
Nascimento, Yasmin Mesquita
Alves, Brenda Elen Bizerra
de Medeiros, Leandro Gurgel
Pereira, Hannaly W. Bezerra
de Paiva, Anne Aline Pereira
Teixeira, Diego G.
Moura, Márcia Cristina Bernardo de Melo
Tavares, Alessandre de Medeiros
Fernandes, José Veríssimo
Jeronimo, Selma M. B.
Araújo, Josélio M. G.
author_facet Monteiro, Joelma D.
Valverde, Joanna Gardel
Morais, Ingryd Camara
Souza, Cassio Ricardo de Medeiros
Fagundes Neto, João Ciro
de Melo, Marília Farias
Nascimento, Yasmin Mesquita
Alves, Brenda Elen Bizerra
de Medeiros, Leandro Gurgel
Pereira, Hannaly W. Bezerra
de Paiva, Anne Aline Pereira
Teixeira, Diego G.
Moura, Márcia Cristina Bernardo de Melo
Tavares, Alessandre de Medeiros
Fernandes, José Veríssimo
Jeronimo, Selma M. B.
Araújo, Josélio M. G.
author_sort Monteiro, Joelma D.
collection PubMed
description The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the state of Rio Grande do Norte, and the aims were to describe the epidemiological and the clinical aspects of the CHIKV outbreak. Biological samples from 284 chikungunya suspected cases were screened for CHIKV and Flavivirus (FV) RNA using qRT-PCR. Negative PCR samples were also screened for anti-CHIKV and anti-FVIgM by ELISA. CHIKV RNA were detected in 125 samples mostly occurring from January through March (46%), mainly affecting adults and older adults. We found a gradual decrease in viral RNA over the disease time. Anti-CHIKV IgM was found in 47.5% after negative CHIKV qRT-PCR. Interestingly, 45.0% simultaneously had positive results for CHIKV and FV IgM, suggesting the occurrence of virus co-circulation. The most frequent symptom was fever (91%). Women presented more chance to develop nausea and abdominal pain compared to men. Our data described and allows us to better understand the clinical and epidemiological aspects of the 2016 chikungunya outbreak in Rio Grande do Norte and can help in the early clinical diagnosis of the virus.
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spelling pubmed-76789672020-12-02 Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil Monteiro, Joelma D. Valverde, Joanna Gardel Morais, Ingryd Camara Souza, Cassio Ricardo de Medeiros Fagundes Neto, João Ciro de Melo, Marília Farias Nascimento, Yasmin Mesquita Alves, Brenda Elen Bizerra de Medeiros, Leandro Gurgel Pereira, Hannaly W. Bezerra de Paiva, Anne Aline Pereira Teixeira, Diego G. Moura, Márcia Cristina Bernardo de Melo Tavares, Alessandre de Medeiros Fernandes, José Veríssimo Jeronimo, Selma M. B. Araújo, Josélio M. G. PLoS One Research Article The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the state of Rio Grande do Norte, and the aims were to describe the epidemiological and the clinical aspects of the CHIKV outbreak. Biological samples from 284 chikungunya suspected cases were screened for CHIKV and Flavivirus (FV) RNA using qRT-PCR. Negative PCR samples were also screened for anti-CHIKV and anti-FVIgM by ELISA. CHIKV RNA were detected in 125 samples mostly occurring from January through March (46%), mainly affecting adults and older adults. We found a gradual decrease in viral RNA over the disease time. Anti-CHIKV IgM was found in 47.5% after negative CHIKV qRT-PCR. Interestingly, 45.0% simultaneously had positive results for CHIKV and FV IgM, suggesting the occurrence of virus co-circulation. The most frequent symptom was fever (91%). Women presented more chance to develop nausea and abdominal pain compared to men. Our data described and allows us to better understand the clinical and epidemiological aspects of the 2016 chikungunya outbreak in Rio Grande do Norte and can help in the early clinical diagnosis of the virus. Public Library of Science 2020-11-20 /pmc/articles/PMC7678967/ /pubmed/33216743 http://dx.doi.org/10.1371/journal.pone.0241799 Text en © 2020 Monteiro et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Monteiro, Joelma D.
Valverde, Joanna Gardel
Morais, Ingryd Camara
Souza, Cassio Ricardo de Medeiros
Fagundes Neto, João Ciro
de Melo, Marília Farias
Nascimento, Yasmin Mesquita
Alves, Brenda Elen Bizerra
de Medeiros, Leandro Gurgel
Pereira, Hannaly W. Bezerra
de Paiva, Anne Aline Pereira
Teixeira, Diego G.
Moura, Márcia Cristina Bernardo de Melo
Tavares, Alessandre de Medeiros
Fernandes, José Veríssimo
Jeronimo, Selma M. B.
Araújo, Josélio M. G.
Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil
title Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil
title_full Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil
title_fullStr Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil
title_full_unstemmed Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil
title_short Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil
title_sort epidemiologic and clinical investigations during a chikungunya outbreak in rio grande do norte state, brazil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678967/
https://www.ncbi.nlm.nih.gov/pubmed/33216743
http://dx.doi.org/10.1371/journal.pone.0241799
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