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Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil
The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the state of Rio Grande do Norte, and the aims were to describe the epidemiologic...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678967/ https://www.ncbi.nlm.nih.gov/pubmed/33216743 http://dx.doi.org/10.1371/journal.pone.0241799 |
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author | Monteiro, Joelma D. Valverde, Joanna Gardel Morais, Ingryd Camara Souza, Cassio Ricardo de Medeiros Fagundes Neto, João Ciro de Melo, Marília Farias Nascimento, Yasmin Mesquita Alves, Brenda Elen Bizerra de Medeiros, Leandro Gurgel Pereira, Hannaly W. Bezerra de Paiva, Anne Aline Pereira Teixeira, Diego G. Moura, Márcia Cristina Bernardo de Melo Tavares, Alessandre de Medeiros Fernandes, José Veríssimo Jeronimo, Selma M. B. Araújo, Josélio M. G. |
author_facet | Monteiro, Joelma D. Valverde, Joanna Gardel Morais, Ingryd Camara Souza, Cassio Ricardo de Medeiros Fagundes Neto, João Ciro de Melo, Marília Farias Nascimento, Yasmin Mesquita Alves, Brenda Elen Bizerra de Medeiros, Leandro Gurgel Pereira, Hannaly W. Bezerra de Paiva, Anne Aline Pereira Teixeira, Diego G. Moura, Márcia Cristina Bernardo de Melo Tavares, Alessandre de Medeiros Fernandes, José Veríssimo Jeronimo, Selma M. B. Araújo, Josélio M. G. |
author_sort | Monteiro, Joelma D. |
collection | PubMed |
description | The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the state of Rio Grande do Norte, and the aims were to describe the epidemiological and the clinical aspects of the CHIKV outbreak. Biological samples from 284 chikungunya suspected cases were screened for CHIKV and Flavivirus (FV) RNA using qRT-PCR. Negative PCR samples were also screened for anti-CHIKV and anti-FVIgM by ELISA. CHIKV RNA were detected in 125 samples mostly occurring from January through March (46%), mainly affecting adults and older adults. We found a gradual decrease in viral RNA over the disease time. Anti-CHIKV IgM was found in 47.5% after negative CHIKV qRT-PCR. Interestingly, 45.0% simultaneously had positive results for CHIKV and FV IgM, suggesting the occurrence of virus co-circulation. The most frequent symptom was fever (91%). Women presented more chance to develop nausea and abdominal pain compared to men. Our data described and allows us to better understand the clinical and epidemiological aspects of the 2016 chikungunya outbreak in Rio Grande do Norte and can help in the early clinical diagnosis of the virus. |
format | Online Article Text |
id | pubmed-7678967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76789672020-12-02 Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil Monteiro, Joelma D. Valverde, Joanna Gardel Morais, Ingryd Camara Souza, Cassio Ricardo de Medeiros Fagundes Neto, João Ciro de Melo, Marília Farias Nascimento, Yasmin Mesquita Alves, Brenda Elen Bizerra de Medeiros, Leandro Gurgel Pereira, Hannaly W. Bezerra de Paiva, Anne Aline Pereira Teixeira, Diego G. Moura, Márcia Cristina Bernardo de Melo Tavares, Alessandre de Medeiros Fernandes, José Veríssimo Jeronimo, Selma M. B. Araújo, Josélio M. G. PLoS One Research Article The first autochthonous case of chikungunya virus (CHIKV) infection in Brazil was in September 2014 in the State of Amapá, and from there it rapidly spread across the country. The present study was conducted in 2016 in the state of Rio Grande do Norte, and the aims were to describe the epidemiological and the clinical aspects of the CHIKV outbreak. Biological samples from 284 chikungunya suspected cases were screened for CHIKV and Flavivirus (FV) RNA using qRT-PCR. Negative PCR samples were also screened for anti-CHIKV and anti-FVIgM by ELISA. CHIKV RNA were detected in 125 samples mostly occurring from January through March (46%), mainly affecting adults and older adults. We found a gradual decrease in viral RNA over the disease time. Anti-CHIKV IgM was found in 47.5% after negative CHIKV qRT-PCR. Interestingly, 45.0% simultaneously had positive results for CHIKV and FV IgM, suggesting the occurrence of virus co-circulation. The most frequent symptom was fever (91%). Women presented more chance to develop nausea and abdominal pain compared to men. Our data described and allows us to better understand the clinical and epidemiological aspects of the 2016 chikungunya outbreak in Rio Grande do Norte and can help in the early clinical diagnosis of the virus. Public Library of Science 2020-11-20 /pmc/articles/PMC7678967/ /pubmed/33216743 http://dx.doi.org/10.1371/journal.pone.0241799 Text en © 2020 Monteiro et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Monteiro, Joelma D. Valverde, Joanna Gardel Morais, Ingryd Camara Souza, Cassio Ricardo de Medeiros Fagundes Neto, João Ciro de Melo, Marília Farias Nascimento, Yasmin Mesquita Alves, Brenda Elen Bizerra de Medeiros, Leandro Gurgel Pereira, Hannaly W. Bezerra de Paiva, Anne Aline Pereira Teixeira, Diego G. Moura, Márcia Cristina Bernardo de Melo Tavares, Alessandre de Medeiros Fernandes, José Veríssimo Jeronimo, Selma M. B. Araújo, Josélio M. G. Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil |
title | Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil |
title_full | Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil |
title_fullStr | Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil |
title_full_unstemmed | Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil |
title_short | Epidemiologic and clinical investigations during a chikungunya outbreak in Rio Grande do Norte State, Brazil |
title_sort | epidemiologic and clinical investigations during a chikungunya outbreak in rio grande do norte state, brazil |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678967/ https://www.ncbi.nlm.nih.gov/pubmed/33216743 http://dx.doi.org/10.1371/journal.pone.0241799 |
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