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Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy

The evaluation of fat-free mass (FFM) in patients with Duchenne muscular dystrophy (DMD) is useful to investigate disease progression and therapeutic efficacy. This study aimed to validate the Bioelectrical impedance (BIA) method compared with the dual-energy X-ray absorptiometry (DXA) for estimatin...

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Autores principales: Grilo, Evellyn C., Cunha, Thais A., Costa, Ádila Danielly S., Araújo, Bárbara G. M., Lopes, Márcia Marília G. D., Maciel, Bruna L. L., Alves, Camila X., Vermeulen-Serpa, Karina M., Dourado-Júnior, Mário Emílio T., Leite-Lais, Lucia, Brandão-Neto, José, Vale, Sancha Helena L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679022/
https://www.ncbi.nlm.nih.gov/pubmed/33216757
http://dx.doi.org/10.1371/journal.pone.0241722
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author Grilo, Evellyn C.
Cunha, Thais A.
Costa, Ádila Danielly S.
Araújo, Bárbara G. M.
Lopes, Márcia Marília G. D.
Maciel, Bruna L. L.
Alves, Camila X.
Vermeulen-Serpa, Karina M.
Dourado-Júnior, Mário Emílio T.
Leite-Lais, Lucia
Brandão-Neto, José
Vale, Sancha Helena L.
author_facet Grilo, Evellyn C.
Cunha, Thais A.
Costa, Ádila Danielly S.
Araújo, Bárbara G. M.
Lopes, Márcia Marília G. D.
Maciel, Bruna L. L.
Alves, Camila X.
Vermeulen-Serpa, Karina M.
Dourado-Júnior, Mário Emílio T.
Leite-Lais, Lucia
Brandão-Neto, José
Vale, Sancha Helena L.
author_sort Grilo, Evellyn C.
collection PubMed
description The evaluation of fat-free mass (FFM) in patients with Duchenne muscular dystrophy (DMD) is useful to investigate disease progression and therapeutic efficacy. This study aimed to validate the Bioelectrical impedance (BIA) method compared with the dual-energy X-ray absorptiometry (DXA) for estimating the %FFM in boys with DMD. This is a cross-sectional study performed with children and adolescents diagnosed with DMD. Resistance and reactance were measured with a BIA analyzer, from which eight predictive equations estimated the %FFM. The %FFM was also determined by DXA and its used as a reference method. Pearson correlation test, coefficient of determination, the root-mean-square error, the interclass correlation coefficient, and linear regression analysis were performed between %FFM values obtained by BIA and DXA. The agreement between these values was verified with the Bland-Altman plot analysis. Forty-six boys aged from 5 to 20 years were enrolled in the study. All the equations showed a correlation between the %FFM estimated by BIA and determined by DXA (p < 0.05). The Bland-Altman method indicated that two equations have a significant bias (p < 0.05) and six equations showed no significant bias of %FFM (p > 0.05). However, one of them has high variation and wide limits of agreement. Five of eight %FFM predictive equations tested in DMD were accurate when compared with the DXA. It can be concluded that BIA is a validity method to evaluate patients with DMD.
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spelling pubmed-76790222020-12-02 Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy Grilo, Evellyn C. Cunha, Thais A. Costa, Ádila Danielly S. Araújo, Bárbara G. M. Lopes, Márcia Marília G. D. Maciel, Bruna L. L. Alves, Camila X. Vermeulen-Serpa, Karina M. Dourado-Júnior, Mário Emílio T. Leite-Lais, Lucia Brandão-Neto, José Vale, Sancha Helena L. PLoS One Research Article The evaluation of fat-free mass (FFM) in patients with Duchenne muscular dystrophy (DMD) is useful to investigate disease progression and therapeutic efficacy. This study aimed to validate the Bioelectrical impedance (BIA) method compared with the dual-energy X-ray absorptiometry (DXA) for estimating the %FFM in boys with DMD. This is a cross-sectional study performed with children and adolescents diagnosed with DMD. Resistance and reactance were measured with a BIA analyzer, from which eight predictive equations estimated the %FFM. The %FFM was also determined by DXA and its used as a reference method. Pearson correlation test, coefficient of determination, the root-mean-square error, the interclass correlation coefficient, and linear regression analysis were performed between %FFM values obtained by BIA and DXA. The agreement between these values was verified with the Bland-Altman plot analysis. Forty-six boys aged from 5 to 20 years were enrolled in the study. All the equations showed a correlation between the %FFM estimated by BIA and determined by DXA (p < 0.05). The Bland-Altman method indicated that two equations have a significant bias (p < 0.05) and six equations showed no significant bias of %FFM (p > 0.05). However, one of them has high variation and wide limits of agreement. Five of eight %FFM predictive equations tested in DMD were accurate when compared with the DXA. It can be concluded that BIA is a validity method to evaluate patients with DMD. Public Library of Science 2020-11-20 /pmc/articles/PMC7679022/ /pubmed/33216757 http://dx.doi.org/10.1371/journal.pone.0241722 Text en © 2020 Grilo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Grilo, Evellyn C.
Cunha, Thais A.
Costa, Ádila Danielly S.
Araújo, Bárbara G. M.
Lopes, Márcia Marília G. D.
Maciel, Bruna L. L.
Alves, Camila X.
Vermeulen-Serpa, Karina M.
Dourado-Júnior, Mário Emílio T.
Leite-Lais, Lucia
Brandão-Neto, José
Vale, Sancha Helena L.
Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy
title Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy
title_full Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy
title_fullStr Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy
title_full_unstemmed Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy
title_short Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy
title_sort validity of bioelectrical impedance to estimate fat-free mass in boys with duchenne muscular dystrophy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679022/
https://www.ncbi.nlm.nih.gov/pubmed/33216757
http://dx.doi.org/10.1371/journal.pone.0241722
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