Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma

Purpose: 12b80 combines doxorubicin bound to a bone targeting hydroxybisphosphonate vector using a pH-sensitive linker, designed to specifically trigger doxorubicin release in an acidic bone tumor microenvironment. This phase I study aimed to determine the safety and toxicity profiles of 12b80 in do...

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Detalles Bibliográficos
Autores principales: Boyé, Pierre, David, Emmanuelle, Serres, François, Pascal, Quentin, Floch, Franck, Geeraert, Kévyn, Coste, Virginie, Marescaux, Laurent, Cagnol, Sébastien, Goujon, Jean-Yves, Egorov, Maxim, Le Bot, Ronan, Tierny, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679038/
https://www.ncbi.nlm.nih.gov/pubmed/33245733
http://dx.doi.org/10.18632/oncotarget.27801

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