Some thoughts on counts in sequencing studies

Measurements in sequencing studies are mostly based on counts. There is a lack of theoretical developments for the analysis and modelling of this type of data. Some thoughts in this direction are presented, which might serve as a seed. The main issues addressed are the compositional character of mul...

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Detalles Bibliográficos
Autores principales: Egozcue, Juan José, Graffelman, Jan, Ortego, M Isabel, Pawlowsky-Glahn, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679068/
https://www.ncbi.nlm.nih.gov/pubmed/33575638
http://dx.doi.org/10.1093/nargab/lqaa094
Descripción
Sumario:Measurements in sequencing studies are mostly based on counts. There is a lack of theoretical developments for the analysis and modelling of this type of data. Some thoughts in this direction are presented, which might serve as a seed. The main issues addressed are the compositional character of multinomial probabilities and the corresponding representation in orthogonal (isometric) coordinates, and modelling distributions for sequencing data taking into account possible effects of amplification techniques.

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