Some thoughts on counts in sequencing studies

Measurements in sequencing studies are mostly based on counts. There is a lack of theoretical developments for the analysis and modelling of this type of data. Some thoughts in this direction are presented, which might serve as a seed. The main issues addressed are the compositional character of mul...

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Detalles Bibliográficos
Autores principales: Egozcue, Juan José, Graffelman, Jan, Ortego, M Isabel, Pawlowsky-Glahn, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679068/
https://www.ncbi.nlm.nih.gov/pubmed/33575638
http://dx.doi.org/10.1093/nargab/lqaa094
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author Egozcue, Juan José
Graffelman, Jan
Ortego, M Isabel
Pawlowsky-Glahn, Vera
author_facet Egozcue, Juan José
Graffelman, Jan
Ortego, M Isabel
Pawlowsky-Glahn, Vera
author_sort Egozcue, Juan José
collection PubMed
description Measurements in sequencing studies are mostly based on counts. There is a lack of theoretical developments for the analysis and modelling of this type of data. Some thoughts in this direction are presented, which might serve as a seed. The main issues addressed are the compositional character of multinomial probabilities and the corresponding representation in orthogonal (isometric) coordinates, and modelling distributions for sequencing data taking into account possible effects of amplification techniques.
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spelling pubmed-76790682021-02-10 Some thoughts on counts in sequencing studies Egozcue, Juan José Graffelman, Jan Ortego, M Isabel Pawlowsky-Glahn, Vera NAR Genom Bioinform Methods Article Measurements in sequencing studies are mostly based on counts. There is a lack of theoretical developments for the analysis and modelling of this type of data. Some thoughts in this direction are presented, which might serve as a seed. The main issues addressed are the compositional character of multinomial probabilities and the corresponding representation in orthogonal (isometric) coordinates, and modelling distributions for sequencing data taking into account possible effects of amplification techniques. Oxford University Press 2020-11-20 /pmc/articles/PMC7679068/ /pubmed/33575638 http://dx.doi.org/10.1093/nargab/lqaa094 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Methods Article
Egozcue, Juan José
Graffelman, Jan
Ortego, M Isabel
Pawlowsky-Glahn, Vera
Some thoughts on counts in sequencing studies
title Some thoughts on counts in sequencing studies
title_full Some thoughts on counts in sequencing studies
title_fullStr Some thoughts on counts in sequencing studies
title_full_unstemmed Some thoughts on counts in sequencing studies
title_short Some thoughts on counts in sequencing studies
title_sort some thoughts on counts in sequencing studies
topic Methods Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679068/
https://www.ncbi.nlm.nih.gov/pubmed/33575638
http://dx.doi.org/10.1093/nargab/lqaa094
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