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Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

The gut wall consists of many biological elements, including enterocytes. Rapid turnover, a prominent feature of the enterocytes, has generally been ignored in the development of enterocyte‐targeting drugs, although it has a comparable rate to other kinetic rates. Here, we investigated the impact of...

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Detalles Bibliográficos
Autores principales:	Takita, Hiroyuki, Darwich, Adam S., Ahmad, Amais, Rostami‐Hodjegan, Amin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679071/ https://www.ncbi.nlm.nih.gov/pubmed/32989926 http://dx.doi.org/10.1002/psp4.12557

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