Physiologically‐Based Pharmacokinetic Modeling for the Prediction of a Drug–Drug Interaction of Combined Effects on P‐glycoprotein and Cytochrome P450 3A

Direct oral anticoagulants, such as apixaban and rivaroxaban, are important for the treatment and prophylaxis of venous thromboembolism and to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Because apixaban and rivaroxaban are predominantly eliminat...

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Detalles Bibliográficos
Autores principales: Otsuka, Yukio, Choules, Mary P., Bonate, Peter L., Komatsu, Kanji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679072/
https://www.ncbi.nlm.nih.gov/pubmed/33030266
http://dx.doi.org/10.1002/psp4.12562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679072/
https://www.ncbi.nlm.nih.gov/pubmed/33030266
http://dx.doi.org/10.1002/psp4.12562

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