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Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study

This study aimed to explore the currently competing and new semimechanistic clearance models for monoclonal antibodies and the impact of clearance model misspecification on exposure metrics under different study designs exemplified for cetuximab. Six clearance models were investigated under four dif...

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Detalles Bibliográficos
Autores principales:	Grisic, Ana‐Marija, Khandelwal, Akash, Bertolino, Mauro, Huisinga, Wilhelm, Girard, Pascal, Kloft, Charlotte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679074/ https://www.ncbi.nlm.nih.gov/pubmed/33015996 http://dx.doi.org/10.1002/psp4.12558

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